Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 8XVK
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146710BDBM50146710(CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146710BDBM50146710(CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146710BDBM50146710(CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...)
Affinity DataIC50: 21.7nMAssay Description:Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)