Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) for PDB: 8Y91
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50021218BDBM50021218(CHEMBL51697 | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  4nMAssay Description:Inhibition of NET in rat synaptosomal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataIC50: 6.60nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50021218BDBM50021218(CHEMBL51697 | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  15.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  20nMAssay Description:Inhibition of rat NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataIC50: 20nMAssay Description:Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  23nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005548BDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  29nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)