Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 8YUT
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22881BDBM22881(5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | CH...)
Affinity DataEC50:  191nMAssay Description:Agonist activity at guinea pig H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22881BDBM22881(5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | CH...)
Affinity DataEC50:  191nMAssay Description:Agonist activity at human H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22881BDBM22881(5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | CH...)
Affinity DataEC50:  617nMAssay Description:Agonist activity at H2R in spontaneously beating guinea pig right atrium assessed as increase in heart rateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22881BDBM22881(5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | CH...)
Affinity DataKd:  5.01E+3nMAssay Description:Compound is evaluated for histamine H2 receptor agonistic activity in guinea pig cerebral cortex using [3H]tiotidine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22881BDBM22881(5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | CH...)
Affinity DataKi:  6.31E+3nMAssay Description:Displacement of [125I]iodoaminopotentidine from human histamine H2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H2 receptor(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22881BDBM22881(5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine | CH...)
Affinity DataKd:  1.15E+4nMAssay Description:Affinity to the Histamine H2 receptor was determined expressed in CHO cell using [125I]iodoaminopotentidine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PDB3D3D Structure (crystal)