Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 8ZP1
LigandChemical structure of BindingDB Monomer ID 35226BDBM35226(Vestra | Reboxetine | (S,S)-reboxetine)
Affinity DataKi:  0.300nM ΔG°:  -56.5kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 35226BDBM35226(Vestra | Reboxetine | (S,S)-reboxetine)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant NET expressed in HEK293 cells assessed as inhibition of [3H]NE reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 35226BDBM35226(Vestra | Reboxetine | (S,S)-reboxetine)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 35226BDBM35226(Vestra | Reboxetine | (S,S)-reboxetine)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 35226BDBM35226(Vestra | Reboxetine | (S,S)-reboxetine)
Affinity DataKi:  15.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMedPDB3D3D Structure (crystal)