Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) for PDB: 9B6G
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 4nMAssay Description:Inhibition of TRPM8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at TRPM8 (unknown origin) assessed as reduction in calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of menthol-induced 45calcium influx treated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 190nMAssay Description:Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of icilin-induced 45calcium influx treated 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 414nMAssay Description:Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 447nMAssay Description:Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase by Fluo-4 AM based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 448nMAssay Description:Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase by Fluo-4 AM based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 589nMAssay Description:Antagonist activity at human recombinant full length TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 6.50E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 7.30E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)