Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 9BFB
TargetSerine/threonine-protein kinase B-raf [V600K](Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 565133BDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 2.70nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600K](Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 565133BDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 2.70nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 565133BDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 3.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 565133BDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 4.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 565146BDBM565146(US11414404, Ex. # 23)
Affinity DataIC50: 16nMAssay Description:Inhibition of BRAF V600E mutant in human A-375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 565146BDBM565146(US11414404, Ex. # 23)
Affinity DataIC50: 52nMAssay Description:Inhibition of 6-His tagged BRAF V600E mutant (445 to 723 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)