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Found 30 Enz. Inhib. hit(s) with all data for entry = 50012898
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50:  7.5nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124017(CHEMBL168909 | N-(1-Formyl-3-methyl-butyl)-3-methy...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124024(2-(4-Chloro-benzenesulfonylamino)-N-[1-formyl-2-(1...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124012(2-(4-Chloro-benzenesulfonylamino)-N-(1-formyl-2-ph...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124022(CHEMBL169307 | N-(1-Formyl-2-phenyl-ethyl)-3-methy...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124019(CHEMBL169551 | N-(1-Formyl-2-phenyl-ethyl)-3-methy...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124018(2-(4-Fluoro-benzenesulfonylamino)-N-[1-formyl-2-(1...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124023(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-2-ph...)
Affinity DataIC50:  27nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124015(CHEMBL168965 | N-(1-Formyl-3-methyl-butyl)-3-methy...)
Affinity DataIC50:  28nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124014(2-(4-Chloro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50:  78nMAssay Description:Inhibitory activity against Cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124016(2-(4-Fluoro-benzenesulfonylamino)-4-methyl-pentano...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124021(2-(4-Fluoro-benzenesulfonylamino)-5-methyl-hexanoi...)
Affinity DataIC50:  260nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124025(2-(4-Fluoro-benzenesulfonylamino)-3-methyl-N-(1-me...)
Affinity DataIC50:  630nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124020(CHEMBL169121 | N-(1-Formyl-3-methyl-butyl)-2-metha...)
Affinity DataIC50:  830nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358145(CHEMBL1923968)
Affinity DataIC50:  1.40E+4nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124013(2-[(4-Fluoro-benzenesulfonyl)-methyl-amino]-N-(1-f...)
Affinity DataIC50:  2.10E+4nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50:  8.10E+4nMAssay Description:Inhibition of Cytochrome P450 3A4 as BFC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against coagulation factor VIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against interleukin 1beta converting enzyme (IL-1 beta converting enzyme)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50:  1.77E+5nMAssay Description:Inhibition of Cytochrome P450 2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibitory activity against ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50:  2.91E+5nMAssay Description:Inhibition of Cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50:  4.92E+5nMAssay Description:Inhibition of Cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50:  5.31E+5nMAssay Description:Inhibition of Cytochrome P450 3A4 as BQ substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358146(CHEMBL1923969)
Affinity DataIC50:  1.00E+6nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50:  1.00E+6nMAssay Description:Inhibition of Cytochrome P450 1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed