Compile Data Set for Download or QSAR
maximum 50k data
Found 38 Enz. Inhib. hit(s) with all data for entry = 50015031
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory concentration against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150525(4-Methyl-2-(4''-piperazin-1-yl-biphenyl-3-ylamino)...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150524((S)-4-Methyl-2-(4''-piperazin-1-yl-biphenyl-2-ylam...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150525(4-Methyl-2-(4''-piperazin-1-yl-biphenyl-3-ylamino)...)
Affinity DataIC50:  24nMAssay Description:Inhibitory concentration against human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150532((S)-4-Methyl-2-(4''-piperazin-1-yl-biphenyl-4-ylam...)
Affinity DataIC50:  26nMAssay Description:Inhibitory concentration against human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150532((S)-4-Methyl-2-(4''-piperazin-1-yl-biphenyl-4-ylam...)
Affinity DataIC50:  27nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150532((S)-4-Methyl-2-(4''-piperazin-1-yl-biphenyl-4-ylam...)
Affinity DataIC50:  34nMAssay Description:Inhibitory concentration against human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150527(2-(4-Bromo-thiophen-3-ylamino)-4-methyl-pentanoic ...)
Affinity DataIC50:  43nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150536(2-(2-Bromo-phenylamino)-4-methyl-pentanoic acid cy...)
Affinity DataIC50:  54nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150526(2-(3-Bromo-phenylamino)-4-methyl-pentanoic acid cy...)
Affinity DataIC50:  72nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150525(4-Methyl-2-(4''-piperazin-1-yl-biphenyl-3-ylamino)...)
Affinity DataIC50:  93nMAssay Description:Inhibitory concentration against human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50:  102nMAssay Description:Inhibitory concentration against human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150525(4-Methyl-2-(4''-piperazin-1-yl-biphenyl-3-ylamino)...)
Affinity DataIC50:  108nMAssay Description:Inhibitory concentration against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150532((S)-4-Methyl-2-(4''-piperazin-1-yl-biphenyl-4-ylam...)
Affinity DataIC50:  115nMAssay Description:Inhibitory concentration against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50:  123nMAssay Description:Inhibitory concentration against human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150524((S)-4-Methyl-2-(4''-piperazin-1-yl-biphenyl-2-ylam...)
Affinity DataIC50:  158nMAssay Description:Inhibitory concentration against human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150527(2-(4-Bromo-thiophen-3-ylamino)-4-methyl-pentanoic ...)
Affinity DataIC50:  158nMAssay Description:Inhibitory concentration against human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150529(2-(4-Bromo-phenylamino)-4-methyl-pentanoic acid cy...)
Affinity DataIC50:  208nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50:  352nMAssay Description:Inhibitory concentration against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150535(2-(2-Bromo-phenylsulfanyl)-4-methyl-pentanoic acid...)
Affinity DataIC50:  433nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150527(2-(4-Bromo-thiophen-3-ylamino)-4-methyl-pentanoic ...)
Affinity DataIC50:  458nMAssay Description:Inhibitory concentration against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150533(2-(4-Bromo-phenylsulfanyl)-4-methyl-pentanoic acid...)
Affinity DataIC50:  675nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150534(2-(3-Bromo-phenylsulfanyl)-4-methyl-pentanoic acid...)
Affinity DataIC50:  684nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150527(2-(4-Bromo-thiophen-3-ylamino)-4-methyl-pentanoic ...)
Affinity DataIC50:  897nMAssay Description:Inhibitory concentration against human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150531(2-(2-Bromo-phenoxy)-4-methyl-pentanoic acid cyanom...)
Affinity DataIC50:  1.15E+3nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150523(2-(3-Bromo-phenoxy)-4-methyl-pentanoic acid cyanom...)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150524((S)-4-Methyl-2-(4''-piperazin-1-yl-biphenyl-2-ylam...)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibitory concentration against human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50:  2.01E+3nMAssay Description:Inhibitory concentration against human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150524((S)-4-Methyl-2-(4''-piperazin-1-yl-biphenyl-2-ylam...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory concentration against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150539(2-(2-Bromo-benzyl)-4-methyl-pentanoic acid cyanome...)
Affinity DataIC50:  2.35E+3nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150537(2-(4-Bromo-benzyl)-4-methyl-pentanoic acid cyanome...)
Affinity DataIC50:  2.39E+3nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150530(2-(4-Bromo-phenoxy)-4-methyl-pentanoic acid cyanom...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150538(2-(3-Bromo-benzyl)-4-methyl-pentanoic acid cyanome...)
Affinity DataIC50:  3.39E+3nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50:  3.73E+3nMAssay Description:Inhibitory concentration against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50:  3.95E+3nMAssay Description:Inhibitory concentration against human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed