Compile Data Set for Download or QSAR
maximum 50k data
Found 63 Enz. Inhib. hit(s) with all data for entry = 50017876
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187848(5-(2,3-dichlorophenylamino)-3-hydroxy-N-(1-hydroxy...)
Affinity DataIC50:  38nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187817(5-(2-chloro-4-iodophenylamino)-3-hydroxy-N-isoprop...)
Affinity DataIC50:  42nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187818(5-(2-chloro-4-iodophenylamino)-3-hydroxy-N-(1-hydr...)
Affinity DataIC50:  44nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187841(3-hydroxy-5-(4-iodo-2-methylphenylamino)-N-isoprop...)
Affinity DataIC50:  62nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187801(5-(2-chloro-4-(trifluoromethyl)phenylamino)-3-hydr...)
Affinity DataIC50:  68nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187855(3-hydroxy-N-(1-hydroxypropan-2-yl)-5-(4-iodo-2-met...)
Affinity DataIC50:  73nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187845(5-(2-chloro-4-(trifluoromethyl)phenylamino)-3-hydr...)
Affinity DataIC50:  86nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187812(5-(2,3-dichlorophenylamino)-3-hydroxy-N-isopropyli...)
Affinity DataIC50:  220nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187815(5-(2,4-dichlorophenylamino)-3-hydroxyisothiazole-4...)
Affinity DataIC50:  250nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187857(CHEMBL377592 | methyl 4-(4-(N-(cyclohexylmethyl)ca...)
Affinity DataIC50:  350nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187852(CHEMBL380328 | N-(cyclohexylmethyl)-5-(2,4-dichlor...)
Affinity DataIC50:  410nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187829(5-(4-chlorophenylamino)-3-hydroxyisothiazole-4-car...)
Affinity DataIC50:  410nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187830(5-(4-chlorophenylamino)-N-(cyclohexylmethyl)-3-hyd...)
Affinity DataIC50:  420nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187850(5-(4-bromophenylamino)-N-(cyclohexylmethyl)-3-hydr...)
Affinity DataIC50:  430nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187813(5-(3-bromophenylamino)-N-(cyclohexylmethyl)-3-hydr...)
Affinity DataIC50:  500nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187831(5-(3-bromophenylamino)-3-hydroxyisothiazole-4-carb...)
Affinity DataIC50:  500nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187838(5-(3-chlorophenylamino)-N-(cyclohexylmethyl)-3-hyd...)
Affinity DataIC50:  500nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187821(3-hydroxy-5-(4-iodophenylamino)-N-isopropylisothia...)
Affinity DataIC50:  510nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187827(5-(2,5-dichlorophenylamino)-3-hydroxyisothiazole-4...)
Affinity DataIC50:  620nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187835(5-(4-chloro-3-(trifluoromethyl)phenylamino)-3-hydr...)
Affinity DataIC50:  650nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187856(CHEMBL378688 | N-(cyclohexylmethyl)-3-hydroxy-5-(2...)
Affinity DataIC50:  670nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187832(CHEMBL209502 | N-(cyclohexylmethyl)-5-(2,4-dimethy...)
Affinity DataIC50:  690nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187858(CHEMBL378833 | N-(cyclohexylmethyl)-5-(3,5-dichlor...)
Affinity DataIC50:  790nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187807(5-(3,5-dichlorophenylamino)-3-hydroxyisothiazole-4...)
Affinity DataIC50:  800nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187822(5-(p-toluidino)-N-(cyclohexylmethyl)-3-hydroxyisot...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187822(5-(p-toluidino)-N-(cyclohexylmethyl)-3-hydroxyisot...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187823(CHEMBL377591 | N-(cyclohexylmethyl)-3-hydroxy-5-(p...)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187805(5-(4-chloro-3-nitrophenylamino)-N-(cyclohexylmethy...)
Affinity DataIC50:  1.39E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187862(CHEMBL213562 | N-(cyclohexylmethyl)-3-hydroxy-5-(2...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187820(3-hydroxy-N-(1-hydroxypropan-2-yl)-5-(4-iodophenyl...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187860(CHEMBL209520 | N-(cyclohexylmethyl)-5-(2-fluorophe...)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187809(5-(p-toluidino)-3-hydroxy-N-(piperidin-1-yl)isothi...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187802(5-(p-toluidino)-N-ethyl-3-hydroxyisothiazole-4-car...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187859(4-(2,3-dihydro-1H-tetrazol-5-yl)-5-(3,5-dimethoxyp...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187853(5-(p-toluidino)-N,3-dihydroxyisothiazole-4-carboxa...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187826(3-hydroxy-5-(1-phenylethylamino)isothiazole-4-carb...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187828(3-hydroxy-5-(2-methoxyphenylamino)isothiazole-4-ca...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187843(3-hydroxy-5-(2-nitrophenylamino)isothiazole-4-carb...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187824(CHEMBL210154 | methyl 3-(4-cyano-3-hydroxyisothiaz...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187836(5-(m-toluidino)-3-hydroxyisothiazole-4-carbonitril...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187839(3-methoxy-4-cyano-5-phenylamino isothiazole | CHEM...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187847(3-hydroxy-5-(3-methoxypropylamino)isothiazole-4-ca...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187825(4-cyano-5-phenylamino-N-methyl-3-isothiazolone | C...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187837(3-hydroxy-5-(4-nitrophenylamino)isothiazole-4-carb...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187819(5-(p-toluidino)-3-hydroxyisothiazole-4-carbonitril...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187840(3-hydroxy-5-(piperidin-1-yl)isothiazole-4-carbonit...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM60829(3-hydroxy-5-[2-(trifluoromethyl)anilino]isothiazol...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187816(5-(cyclohexylmethylamino)-3-hydroxyisothiazole-4-c...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187814(3-hydroxy-5-(4-phenoxyphenoxy)isothiazole-4-carbon...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50187811(5-(4-cyanophenylamino)-3-hydroxyisothiazole-4-carb...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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