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Found 176 Enz. Inhib. hit(s) with all data for entry = 50030495
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297088((S)-2-phenoxy-N-phenyl-N-(pyrrolidin-3-yl)benzamid...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to rat NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297098((S)-N-cyclohexyl-2-(methylthio)-N-(pyrrolidin-3-yl...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262415((S)-N-(biphenyl-2-ylmethyl)-N-(pyrrolidin-3-yl)iso...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297078((S)-N-(cyclobutylmethyl)-2-(ethylthio)-N-(pyrrolid...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297081((S)-N-(cyclobutylmethyl)-2-phenoxy-N-(pyrrolidin-3...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297091((S)-N-(cyclobutylmethyl)-2-(methylthio)-N-(pyrroli...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262678((S)-ethyl biphenyl-2-ylmethyl(pyrrolidin-3-yl)carb...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297087((S)-N-isobutyl-2-phenoxy-N-(pyrrolidin-3-yl)benzam...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297085((S)-N-ethyl-2-phenoxy-N-(pyrrolidin-3-yl)benzamide...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297096((S)-N-cyclopentyl-2-(methylthio)-N-(pyrrolidin-3-y...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297079((S)-N-(cyclobutylmethyl)-2-isopropyl-N-(pyrrolidin...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50236389(CHEMBL273208 | N-methyl(6-methyl-4-(2-phenoxypheno...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297086((S)-N-cyclobutyl-2-phenoxy-N-(pyrrolidin-3-yl)benz...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297082((S)-N-cyclobutyl-2-(methylthio)-N-(pyrrolidin-3-yl...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297098((S)-N-cyclohexyl-2-(methylthio)-N-(pyrrolidin-3-yl...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297080((S)-N-(cyclobutylmethyl)-2-cyclopentyl-N-(pyrrolid...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297106((S)-N-(cyclopentylmethyl)-2-isopropyl-N-(pyrrolidi...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297097((S)-2-(methylthio)-N-phenyl-N-(pyrrolidin-3-yl)ben...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297093((S)-2-chloro-N-(cyclobutylmethyl)-N-(pyrrolidin-3-...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297092((S)-N-(cyclobutylmethyl)-2-ethoxy-N-(pyrrolidin-3-...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297102((S)-N-(cyclopentylmethyl)-N-(pyrrolidin-3-yl)-2-(t...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297083((S)-N-phenyl-N-(pyrrolidin-3-yl)-2-(trifluoromethy...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297094((S)-N-(cyclobutylmethyl)-2-ethyl-N-(pyrrolidin-3-y...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297101((S)-N-(cyclopropylmethyl)-N-(pyrrolidin-3-yl)-2-(t...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297104((S)-N-(cyclopropylmethyl)-2-isopropyl-N-(pyrrolidi...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297084((S)-N-cyclopentyl-2-isopropyl-N-(pyrrolidin-3-yl)b...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297096((S)-N-cyclopentyl-2-(methylthio)-N-(pyrrolidin-3-y...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297095((S)-2-(methylthio)-N-propyl-N-(pyrrolidin-3-yl)ben...)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297111((R)-N-(cyclobutylmethyl)-2-phenoxy-N-(pyrrolidin-3...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297093((S)-2-chloro-N-(cyclobutylmethyl)-N-(pyrrolidin-3-...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297103((S)-N-cyclobutyl-2-isopropyl-N-(pyrrolidin-3-yl)be...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297100((S)-N-cyclobutyl-N-(pyrrolidin-3-yl)-2-(trifluorom...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297107((S)-N-methyl-2-phenoxy-N-(pyrrolidin-3-yl)benzamid...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297082((S)-N-cyclobutyl-2-(methylthio)-N-(pyrrolidin-3-yl...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297097((S)-2-(methylthio)-N-phenyl-N-(pyrrolidin-3-yl)ben...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297088((S)-2-phenoxy-N-phenyl-N-(pyrrolidin-3-yl)benzamid...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297090((S)-N-(cyclobutylmethyl)-2-methyl-N-(pyrrolidin-3-...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297105((S)-2-isopropyl-N-propyl-N-(pyrrolidin-3-yl)benzam...)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297102((S)-N-(cyclopentylmethyl)-N-(pyrrolidin-3-yl)-2-(t...)
Affinity DataKi:  109nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297083((S)-N-phenyl-N-(pyrrolidin-3-yl)-2-(trifluoromethy...)
Affinity DataKi:  113nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297090((S)-N-(cyclobutylmethyl)-2-methyl-N-(pyrrolidin-3-...)
Affinity DataKi:  118nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297112((S)-N-(pyrrolidin-3-yl)-N-(2-(trifluoromethyl)benz...)
Affinity DataKi:  148nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297081((S)-N-(cyclobutylmethyl)-2-phenoxy-N-(pyrrolidin-3...)
Affinity DataKi:  151nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297087((S)-N-isobutyl-2-phenoxy-N-(pyrrolidin-3-yl)benzam...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297099((S)-N-isopropyl-N-(pyrrolidin-3-yl)-2-(trifluorome...)
Affinity DataKi:  172nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297091((S)-N-(cyclobutylmethyl)-2-(methylthio)-N-(pyrroli...)
Affinity DataKi:  179nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297112((S)-N-(pyrrolidin-3-yl)-N-(2-(trifluoromethyl)benz...)
Affinity DataKi:  187nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297100((S)-N-cyclobutyl-N-(pyrrolidin-3-yl)-2-(trifluorom...)
Affinity DataKi:  210nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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