Compile Data Set for Download or QSAR
maximum 50k data
Found 49 Enz. Inhib. hit(s) with all data for entry = 50031468
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313839((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313846((R)-5-(4-fluorophenyl)-5-((5-hydroxy-1-oxoisoindol...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313842((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313843((R)-5-(furan-2-yl)-5-((6-methoxy-1-oxoisoindolin-2...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313841((R)-5-(4-fluorophenyl)-5-((6-methoxy-1-oxoisoindol...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313844((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313838((R)-5-(4-hydroxyphenyl)-5-((6-methoxy-1-oxoisoindo...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313851((+/-)-5-(4-fluorophenyl)-5-((5-((2-methylquinolin-...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313848((R)-5-((5-(cyclopropylmethoxy)-1-oxoisoindolin-2-y...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313845((+/-)-5-((5-methoxy-1-oxoisoindolin-2-yl)methyl)-5...)
Affinity DataKi:  3nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313835((+/-)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313825((+/-)-5-(4-fluorophenyl)-5-((1-oxoisoindolin-2-yl)...)
Affinity DataKi:  4nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313831((+/-)-5-(4-fluorophenyl)-5-((6-methoxy-1-oxo-1H-py...)
Affinity DataKi:  5nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313840((+/-)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-...)
Affinity DataKi:  5.5nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313824(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  6nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313847((+/-)-5-((5-chloro-1-oxoisoindolin-2-yl)methyl)-5-...)
Affinity DataKi:  7nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313849((+/-)-5-(4-fluorophenyl)-5-((1-oxo-5-(pyridin-4-yl...)
Affinity DataKi:  9nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313836((+/-)-5-((6-fluoro-1-oxoisoindolin-2-yl)methyl)-5-...)
Affinity DataKi:  9nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313832((+/-)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5...)
Affinity DataKi:  10nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313837((+/-)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-...)
Affinity DataKi:  10nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  23nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313819(5-((6-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  28nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313823(5-((5,6-dimethoxy-3-oxo-1H-indazol-2(3H)-yl)methyl...)
Affinity DataKi:  53nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313833((R)-5-ethyl-5-((6-methoxy-1-oxoisoindolin-2-yl)met...)
Affinity DataKi:  56nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313822(5-((6-(benzyloxy)-3-oxo-1H-indazol-2(3H)-yl)methyl...)
Affinity DataKi:  100nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313839((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi:  176nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313820(5-((5-ethoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-m...)
Affinity DataKi:  209nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313839((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi:  245nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313850((R)-5-((5-(2-cyclohexylethoxy)-1-oxoisoindolin-2-y...)
Affinity DataKi:  332nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313821(5-((5-(benzyloxy)-3-oxo-1H-indazol-2(3H)-yl)methyl...)
Affinity DataKi:  391nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313834((R)-5-benzyl-5-((6-methoxy-1-oxoisoindolin-2-yl)me...)
Affinity DataKi: >500nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313826((+/-)-5-(1,1-Dioxo-1,3-dihydro-1lambda*6*-benzo[d]...)
Affinity DataKi:  1.05E+3nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313839((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313839((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi:  1.21E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313827((+/-)-5-(4-fluorophenyl)-5-((3-oxotetrahydroimidaz...)
Affinity DataKi:  2.73E+3nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313829((+/-)-5-methyl-5-((7-oxo-5H-pyrrolo[3,4-b]pyridin-...)
Affinity DataKi:  4.82E+3nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of ADAM9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  1.29E+4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313830((+/-)-5-methyl-5-((5-oxo-5H-pyrrolo[3,4-b]pyridin-...)
Affinity DataKi:  2.49E+4nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  3.19E+4nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313839((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313839((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313839((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313839((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313828((+/-)-5-(4-fluorophenyl)-5-((3-oxo-1H-pyrrolo[1,2-...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed