Compile Data Set for Download or QSAR
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Found 135 Enz. Inhib. hit(s) with all data for entry = 50031858
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16735(N-(2-{4-[(3R)-3-hydroxy-3-phenylpropyl]piperazin-1...)
Affinity DataIC50:  46nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16733(4-[1-(5-Amino)-pentyl]-1-{4-(phenyl)-2-[(naphthale...)
Affinity DataIC50:  68nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16734(N-(2-{4-[(3S)-3-hydroxy-3-phenylpropyl]piperazin-1...)
Affinity DataIC50:  69nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16727(N-{5-bromo-2-[4-(2-hydroxyethyl)piperazin-1-yl]phe...)
Affinity DataIC50:  79nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16736(N-[2-(4-benzoylpiperazin-1-yl)-5-phenylphenyl]naph...)
Affinity DataIC50:  79nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16731(Naphthyl Compound, 5b | ethyl 2-{4-[2-(naphthalene...)
Affinity DataIC50:  90nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16732(1-{4-(Phenyl)-2-[(naphthalene-1-carbonyl)-amino]-p...)
Affinity DataIC50:  100nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16730(N-{2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-phenylph...)
Affinity DataIC50:  110nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16749(Coumarin Compound, 11c | N-[2-(4-benzylpiperazin-1...)
Affinity DataIC50:  151nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16729(N-[5-phenyl-2-(piperazin-1-yl)phenyl]naphthalene-1...)
Affinity DataIC50:  300nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16750(2,2,2-trifluoroacetic acid; 2-oxo-N-[5-phenyl-2-(p...)
Affinity DataIC50:  580nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16742(Coumarin Compound, 9e | N-{5-bromo-2-[4-(2-hydroxy...)
Affinity DataIC50:  630nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16741(2,2,2-trifluoroacetic acid; N-[5-bromo-2-(piperazi...)
Affinity DataIC50:  670nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16740(CHEMBL206442 | Coumarin Compound, 9c | N-[2-(4-ben...)
Affinity DataIC50:  760nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16739(CHEMBL207083 | Coumarin Compound, 9b | tert-butyl ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16744(CHEMBL206854 | Coumarin Compound, 10b | tert-butyl...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16726(CHEMBL203120 | N-[5-bromo-2-(piperazin-1-yl)phenyl...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16747(Coumarin Compound, 10e | N-{5-bromo-2-[4-(2-hydrox...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16724(CHEMBL381618 | Naphthyl Compound, 3b | tert-butyl ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320690(1-{[3-(4-Chloro-phenylcarbamoyl)-phenylcarbamoyl]-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16728(N-[2-(4-benzylpiperazin-1-yl)-5-phenylphenyl]napht...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16046(3-{[(5-aminopentyl)carbamoyl]methoxy}-5-{[(1R)-1-(...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320694(3-Carbamoyl-1-{[3-(4-methoxy-phenylcarbamoyl)-phen...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320698(1-{[3-(4-Methyl-benzoylamino)-phenylcarbamoyl]-met...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16044(3-{[(5-aminopentyl)carbamoyl]methoxy}-5-{[(1R)-1-p...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320691(1-{[3-(4-Methoxy-phenylcarbamoyl)-phenylcarbamoyl]...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320600(1-{4-(4'-chlorophenyl)-2-[(naphthalene-1-carbonyl)...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320696(3-Phenethylcarbamoyl-1-[(3-p-tolylcarbamoyl-phenyl...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16725(CHEMBL380521 | N-[2-(4-benzylpiperazin-1-yl)-5-bro...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16746(2,2,2-trifluoroacetic acid; N-[5-bromo-2-(piperazi...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16745(CHEMBL381617 | Coumarin Compound, 10c | N-[2-(4-be...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320629(2-chloro-5-(5-((2-(4-(4-fluorophenylamino)-6-morph...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16409(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16743(Coumarin Compound, 10a | N-[5-bromo-2-(morpholin-4...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16738(Coumarin Compound, 9a | N-[5-bromo-2-(morpholin-4-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320606(2-((2-(4,6-bis(phenylamino)-1,3,5-triazin-2-yl)hyd...)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320618(4-ethoxy-6-(2-(4-iodo-2-methylphenyl)hydrazinyl)-N...)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320697(1-{[3-(4-Chloro-phenylcarbamoyl)-phenylcarbamoyl]-...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320692(1{[3-(4-Methyl-benzoylamino)-phenylcarbamoyl]-meth...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16414(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16412(1-N-[(2S,3R)-4-(tert-butylamino)-3-hydroxy-1-pheny...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16411(1-N-[(2S,3R)-4-(ethylamino)-3-hydroxy-1-phenylbuta...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16723(N-[5-bromo-2-(morpholin-4-yl)phenyl]naphthalene-1-...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320613(2,4-dibromo-6-((2-(4-(3-chloro-4-methylphenylamino...)
Affinity DataIC50:  2.06E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16043(3-{[(5-aminopentyl)carbamoyl]methoxy}-5-(2-cyanoph...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16410(1-N-[(2S,3R)-4-amino-3-hydroxy-1-phenylbutan-2-yl]...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320632((R)-5-(2-(5-aminopentylamino)-2-oxoethoxy)-N1-(1-p...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320610(2-((2-(4,6-bis(phenylamino)-1,3,5-triazin-2-yl)hyd...)
Affinity DataIC50:  2.55E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM50320626(5-(5-((2-(4-(4-fluorophenylamino)-6-(piperidin-1-y...)
Affinity DataIC50:  2.79E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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