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Found 39 Enz. Inhib. hit(s) with all data for entry = 50040568
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50353441(CHEMBL1829786)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50382459(CHEMBL2023986 | US10196373, Compound 27NH)
Affinity DataKi:  1.67E+4nMAssay Description:Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396178(CHEMBL2172014)
Affinity DataKi:  1.87E+4nMAssay Description:Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50382461(CHEMBL2023987 | US10196373, Compound 27KG)
Affinity DataKi:  2.15E+4nMAssay Description:Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396179(CHEMBL2172013)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataKi:  8.00E+4nMAssay Description:Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50423685(CHEMBL502473)
Affinity DataIC50:  150nMAssay Description:Inhibition of STAT3 assessed as suppression of STAT3-DNA interaction by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396176(CHEMBL207155)
Affinity DataIC50:  280nMAssay Description:Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM53072((5Z)-3-allyl-5-(3-ethyl-1,3-benzothiazol-2-ylidene...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of STAT3 expressed in human HCT116 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396169(CHEMBL1337170)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of STAT3 SH2 domain using 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2 as substrate preincubated for 60 mins prior to substrate addition by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 1-alpha/beta(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396176(CHEMBL207155)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of STAT1 SH2 domain assessed as inhibition of STAT1 SH2-phosphotyrosine interaction by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396172(CHEMBL2172008)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of IL6-mediated STAT3 phosphorylation in human HepG2 cells preincubated for 1 hr prior to IL6 challenge measured after 30 mins by immunobl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396170(CHEMBL2031566)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of recombinant STAT3 assessed as inhibition of STAT3-phosphododecapeptide interaction by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396180(CHEMBL2171897)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396181(CHEMBL2172017)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396172(CHEMBL2172008)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of recombinant STAT3 assessed as inhibition of STAT3-phosphododecapeptide interaction by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396183(CHEMBL2172015)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50353441(CHEMBL1829786)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20273((2S)-2-[(2S)-2-[(4-cyanophenyl)formamido]-3-[4-(ph...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396179(CHEMBL2172013)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50382459(CHEMBL2023986 | US10196373, Compound 27NH)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396178(CHEMBL2172014)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50382461(CHEMBL2023987 | US10196373, Compound 27KG)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20282(4-{[4-(hexylcarbamoyl)-2-(naphthalen-1-yl)-1,3-oxa...)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396171(CHEMBL2172009)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of IL6-mediated STAT3 phosphorylation in human HepG2 cells preincubated for 1 hr prior to IL6 challenge measured after 30 mins by immunobl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396173(CHEMBL2171900)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of IL6-mediated STAT3 phosphorylation in human HepG2 cells preincubated for 1 hr prior to IL6 challenge measured after 30 mins by immunobl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396170(CHEMBL2031566)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of IL6-mediated STAT3 phosphorylation in human HepG2 cells preincubated for 1 hr prior to IL6 challenge measured after 30 mins by immunobl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibition of STAT3 dimerization in EGF-stimulated mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396182(CHEMBL2172016)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396175(CHEMBL2171898)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of IL6-mediated STAT3 phosphorylation in human HepG2 cells preincubated for 1 hr prior to IL6 challenge measured after 30 mins by immunobl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396171(CHEMBL2172009)
Affinity DataIC50:  1.14E+5nMAssay Description:Inhibition of recombinant STAT3 assessed as inhibition of STAT3-phosphododecapeptide interaction by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396173(CHEMBL2171900)
Affinity DataIC50:  1.37E+5nMAssay Description:Inhibition of recombinant STAT3 assessed as inhibition of STAT3-phosphododecapeptide interaction by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396174(CHEMBL2171899)
Affinity DataIC50:  1.44E+5nMAssay Description:Inhibition of IL6-mediated STAT3 phosphorylation in human HepG2 cells preincubated for 1 hr prior to IL6 challenge measured after 30 mins by immunobl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396174(CHEMBL2171899)
Affinity DataIC50:  2.56E+5nMAssay Description:Inhibition of recombinant STAT3 assessed as inhibition of STAT3-phosphododecapeptide interaction by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 1(Mus musculus)
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of STAT1 dimerization in EGF-stimulated mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT1-DNA interaction aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396175(CHEMBL2171898)
Affinity DataIC50:  4.47E+5nMAssay Description:Inhibition of recombinant STAT3 assessed as inhibition of STAT3-phosphododecapeptide interaction by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50396177(NIFUROXAZIDE)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of STAT3 expressed in human U3A cells after 1 hr by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50353441(CHEMBL1829786)
Affinity DataKd:  2.74E+3nMAssay Description:Binding affinity to STAT3 SH2 in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed