Compile Data Set for Download or QSAR
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Found 119 Enz. Inhib. hit(s) with all data for entry = 50040661
LigandPNGBDBM50398003(CHEMBL2180402)
Affinity DataKi:  0.100nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398003(CHEMBL2180402)
Affinity DataKi:  0.100nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398012(CHEMBL2180422 | US8492392, 1-17)
Affinity DataKi:  0.630nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398013(CHEMBL2180421 | US8492392, K-2)
Affinity DataKi:  0.900nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398011(CHEMBL2180423 | US8492392, O-2)
Affinity DataKi:  0.920nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398004(CHEMBL2180401)
Affinity DataKi:  0.950nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398008(CHEMBL2180426)
Affinity DataKi:  2nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM119778(CHEMBL2180429 | US8691827, I-9)
Affinity DataKi:  2.20nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398005(CHEMBL2180430 | US8691827, I-8)
Affinity DataKi:  15nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398007(CHEMBL2180428 | US8691827, I-1)
Affinity DataKi:  48nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398010(CHEMBL2180424)
Affinity DataKi:  87nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50003980(CHEMBL2180434)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003984(CHEMBL2180437)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003983(CHEMBL2180435)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003985(CHEMBL2180436)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003979(CHEMBL2180433)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003982(CHEMBL2180432)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003981(CHEMBL2180431)
Affinity DataKi: <1.00E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398009(CHEMBL2180425)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of PDE10A by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397973(CHEMBL2180441)
Affinity DataIC50:  0.00330nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397987(CHEMBL2180452)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004081(CHEMBL2180797)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397999(CHEMBL2180796)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
LigandPNGBDBM50398000(CHEMBL2180795)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
LigandPNGBDBM50397988(CHEMBL2180806)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397972(CHEMBL2180442)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397977(CHEMBL2180420)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390812(CHEMBL2069321)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
LigandPNGBDBM31596(substituted pyrazole, 13)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant PDE10A by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398017(CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of PDE10A using [3H]cAMP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398015(CHEMBL2180413 | US9018217, 5,7-dimethyl-2-(2-(1-me...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of PDE10A using [3H]cAMP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397978(CHEMBL2180419)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397976(CHEMBL2180438)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397971(CHEMBL2180443)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397966(CHEMBL2180775)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397974(CHEMBL2180440)
Affinity DataIC50:  0.890nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397989(CHEMBL2180805 | US8759532, 32)
Affinity DataIC50:  0.960nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM97529(Roche-Dataset for PDE10A, Compound 46 | US8470820,...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM97527(Roche-Dataset for PDE10A, Compound 53 | US8470820,...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397979(CHEMBL2180418 | US8927738, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397964(CHEMBL2180790)
Affinity DataIC50:  1nMAssay Description:Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390829(CHEMBL2070666)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397993(CHEMBL2180406)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397998(CHEMBL2180800 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397970(CHEMBL2180771)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of recombinant PDE2A expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397975(CHEMBL2180439)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390822(CHEMBL2070659)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397980(CHEMBL2180417)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397981(CHEMBL2180416)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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