Compile Data Set for Download or QSAR
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Found 8 Enz. Inhib. hit(s) with all data for entry = 50010247
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  89nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged C-terminal His6-tagged MEK1 expressed in Escherichia coli using myelin basic protei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50:  91nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged C-terminal His6-tagged MEK1 expressed in Escherichia coli using myelin basic protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50:  610nMAssay Description:Inhibition of MEK1 in BRAF mutant human A549 cells assessed as reduction in ERK1/2 phosphorylation by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50:  1.56E+4nMAssay Description:Inhibition of FAK in human MCF7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed