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Found 27 Enz. Inhib. hit(s) with all data for entry = 50009949
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of JAK3 (unknown origin) measured after 1 hr in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533709(CHEMBL4564551)
Affinity DataIC50:  42nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533711(CHEMBL4460736)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533704(CHEMBL4475579)
Affinity DataIC50:  64nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533706(CHEMBL4474787)
Affinity DataIC50:  67nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533712(CHEMBL4518995)
Affinity DataIC50:  72nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533713(CHEMBL4445037)
Affinity DataIC50:  72nMAssay Description:Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533713(CHEMBL4445037)
Affinity DataIC50:  74nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533707(CHEMBL4537821)
Affinity DataIC50:  82nMAssay Description:Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533707(CHEMBL4537821)
Affinity DataIC50:  96nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533704(CHEMBL4475579)
Affinity DataIC50:  138nMAssay Description:Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533706(CHEMBL4474787)
Affinity DataIC50:  142nMAssay Description:Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533705(CHEMBL4473540)
Affinity DataIC50:  156nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533708(CHEMBL4458964)
Affinity DataIC50:  165nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533708(CHEMBL4458964)
Affinity DataIC50:  186nMAssay Description:Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533710(CHEMBL4459730)
Affinity DataIC50:  210nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  428nMAssay Description:Inhibition of JAK3 (unknown origin) measured after 1 hr in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533709(CHEMBL4564551)
Affinity DataIC50:  444nMAssay Description:Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533714(CHEMBL4447949)
Affinity DataIC50:  511nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533715(CHEMBL4467032)
Affinity DataIC50:  786nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533713(CHEMBL4445037)
Affinity DataIC50:  1.76E+3nMAssay Description:Inhibition of JAK3 (unknown origin) measured after 1 hr in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50533709(CHEMBL4564551)
Affinity DataIC50:  2.44E+3nMAssay Description:Inhibition of JAK3 (unknown origin) measured after 1 hr in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Mus musculus)
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataEC50:  186nMAssay Description:Inhibition of JAK2 V617F mutant expressed in mouse BaF3 cells cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair