Compile Data Set for Download or QSAR
maximum 50k data
Found 70 Enz. Inhib. hit(s) with all data for entry = 50018895
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))TBA
LigandPNGBDBM50613682(CHEMBL5276995)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
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TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
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TargetFocal adhesion kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50246060(CHEMBL472212 | CHEMBL541649 | D3RKN_6 | N-methyl-N...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
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TargetCyclin-dependent kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
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TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))TBA
LigandPNGBDBM50613682(CHEMBL5276995)
Affinity DataIC50:  5nMAssay Description:Inhibition of PLK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM26479(4-N-(3-methyl-1H-indazol-6-yl)-2-N-(3,4,5-trimetho...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50613680(CHEMBL5285509)
Affinity DataIC50:  8nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))TBA
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)
Affinity DataIC50:  9nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
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TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))TBA
LigandPNGBDBM50246060(CHEMBL472212 | CHEMBL541649 | D3RKN_6 | N-methyl-N...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PYK2 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))TBA
LigandPNGBDBM50099349(2-(2,3-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
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TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50099349(2-(2,3-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of P38alphaMAPK (unknown origin)More data for this Ligand-Target Pair
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TargetRibosomal protein S6 kinase alpha-6(Homo sapiens (Human))TBA
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  15nMAssay Description:Inhibition of RSK4 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  17nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
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TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)
Affinity DataIC50:  17nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
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TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50431381(FOSTAMATINIB | R-788 Free acid | R-935788 Free aci...)
Affinity DataIC50:  17nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
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TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))TBA
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human RSK3More data for this Ligand-Target Pair
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TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))TBA
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  18nMAssay Description:Inhibition of RSK3 (unknown origin)More data for this Ligand-Target Pair
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TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))TBA
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  24nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  25nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
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TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50099334(4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50:  25nMAssay Description:Inhibition of P38alphaMAPK (unknown origin)More data for this Ligand-Target Pair
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TargetMitogen-activated protein kinase 11(Homo sapiens (Human))TBA
LigandPNGBDBM50099334(4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50:  25nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  27nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant full-length GSK3alpha expressed in Escherichia coli incubated for 2 hrsMore data for this Ligand-Target Pair
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TargetCyclin-dependent kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))TBA
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50:  31nMAssay Description:Inhibition of RSK1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50:  32nMAssay Description:Inhibition of BRD2/3 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)
Affinity DataIC50:  34nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
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TargetBromodomain testis-specific protein(Homo sapiens (Human))TBA
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  35nMAssay Description:Inhibition of BRDT (unknown origin)More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613683(CHEMBL5270270)
Affinity DataIC50:  44nMAssay Description:Inhibition of EGFR (unknown origin) using flurogenic substrate in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50:  50nMAssay Description:Inhibition of P38alphaMAPK (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))TBA
LigandPNGBDBM50613682(CHEMBL5276995)
Affinity DataIC50:  56nMAssay Description:Inhibition of PLK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50:  94nMAssay Description:Inhibition of human recombinant full-length GSK3beta expressed in Escherichia coli incubated for 2 hrsMore data for this Ligand-Target Pair
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TargetCyclin-dependent kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50613680(CHEMBL5285509)
Affinity DataIC50:  100nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMitogen-activated protein kinase 11(Homo sapiens (Human))TBA
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50:  100nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))TBA
LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human N-terminal His6-tagged BRDT (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 1 hrMore data for this Ligand-Target Pair
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LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)
Affinity DataIC50:  158nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)
Affinity DataIC50:  169nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
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TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  170nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50427453(CHEMBL2322228 | US10308662, Compound 28 | US950578...)
Affinity DataIC50:  280nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
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TargetBromodomain testis-specific protein(Homo sapiens (Human))TBA
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  290nMAssay Description:Inhibition of human N-terminal His6-tagged BRDT (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 1 hrMore data for this Ligand-Target Pair
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TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))TBA
LigandPNGBDBM50613680(CHEMBL5285509)
Affinity DataIC50:  410nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMitogen-activated protein kinase 11(Homo sapiens (Human))TBA
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50:  500nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  714nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
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TargetBromodomain testis-specific protein(Homo sapiens (Human))TBA
LigandPNGBDBM50613679(CHEMBL5287725)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human BRDTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
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