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Found 11 Enz. Inhib. hit(s) with all data for entry = 50000711
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259245(CHEMBL4064127 | US10266550, Compound 17a)
Affinity DataIC50:  970nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50:  1.56E+4nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259213(CHEMBL4079855 | US10266550, Compound 7e)
Affinity DataIC50:  1.25E+5nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259246(CHEMBL4066307 | US10266550, Compound 10a)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259212(CHEMBL2002459 | US10266550, Compound 1)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed