Compile Data Set for Download or QSAR
maximum 50k data
Found 118 Enz. Inhib. hit(s) with all data for entry = 50000517
TargetHistone deacetylase 3(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM24622(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Affinity DataKi:  10nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM24622(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Affinity DataKi:  10nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM24622(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Affinity DataKi:  20nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM24622(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Affinity DataKi:  20nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM24622(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Affinity DataKi:  20nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM24622(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Affinity DataKi:  280nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252391(CHEMBL4080014)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  2nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus expression system in Sf9 cells using AMC-labeled RHKKAc as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252394(CHEMBL4090165)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human HDAC3 using Boc-Lys (Ac)-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataIC50:  4nMAssay Description:Inhibition of human HDAC6 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252396(CHEMBL4077645)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(acetyl)-AMC as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Zea mays)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50105329(CHEMBL1213492)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of maize HD1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252392(CHEMBL4069287)
Affinity DataIC50:  8nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252390(CHEMBL4104247)
Affinity DataIC50:  8nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC7 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252393(CHEMBL4060412)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252394(CHEMBL4090165)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys (Ac)-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252388(CHEMBL4079541)
Affinity DataIC50:  25nMAssay Description:Inhibition of human HDAC6 after 15 mins by trypsin-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252394(CHEMBL4090165)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant human HDAC1 using Boc-Lys (Ac)-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252394(CHEMBL4090165)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant human HDAC2 using Boc-Lys (Ac)-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252391(CHEMBL4080014)
Affinity DataIC50:  30nMAssay Description:Inhibition of HDAC7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252389(CHEMBL4103801)
Affinity DataIC50:  37nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50:  56nMAssay Description:Inhibition of human HDAC6 after 15 mins by trypsin-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  70nMAssay Description:Inhibition of C-terminal GST-tagged full length human HDAC1 expressed in baculovirus expression system in Sf9 cells using AMC-labeled RHKKAc as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252393(CHEMBL4060412)
Affinity DataIC50:  70nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252391(CHEMBL4080014)
Affinity DataIC50:  70nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  80nMAssay Description:Inhibition of C-terminal His-tagged full length human HDAC3 expressed in baculovirus expression system using AMC-labeled RHKKAc as substrate after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252392(CHEMBL4069287)
Affinity DataIC50:  100nMAssay Description:Inhibition of HDAC7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252383(CHEMBL4105617)
Affinity DataIC50:  150nMAssay Description:Inhibition of HDAC8 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  150nMAssay Description:Inhibition of full length human HDAC8 expressed in an E. coli expression system using AMC-labeled RHKAcKAc as substrate after 2 hrs by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  160nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus expression system after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  160nMAssay Description:Inhibition of C-terminal His-tagged full length human HDAC2 expressed in baculovirus expression system in Sf9 cells using AMC-labeled RHKKAc as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252391(CHEMBL4080014)
Affinity DataIC50:  200nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252392(CHEMBL4069287)
Affinity DataIC50:  200nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252391(CHEMBL4080014)
Affinity DataIC50:  200nMAssay Description:Inhibition of HDAC5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  220nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC5 expressed in baculovirus expression system in Sf9 cells using AMC-labeled RHKKAc as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataIC50:  250nMAssay Description:Inhibition of human HDAC8 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252394(CHEMBL4090165)
Affinity DataIC50:  280nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as inhibition of CpGB-induced NF-kappaB activation after 24 hrs by spectrophotom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  290nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus expression system using AMC-labeled RHKKAc as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  290nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC10 (1 to 631 residues) expressed in baculovirus expression system in Sf9 cells RHKAcKAc after 2 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  340nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC11 expressed in baculovirus expression systemRHKAcKAc after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252392(CHEMBL4069287)
Affinity DataIC50:  400nMAssay Description:Inhibition of HDAC5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252388(CHEMBL4079541)
Affinity DataIC50:  400nMAssay Description:Inhibition of human HDAC8 after 15 mins by trypsin-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252391(CHEMBL4080014)
Affinity DataIC50:  500nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252392(CHEMBL4069287)
Affinity DataIC50:  600nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252388(CHEMBL4079541)
Affinity DataIC50:  700nMAssay Description:Inhibition of human HDAC10 after 15 mins by trypsin-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50252388(CHEMBL4079541)
Affinity DataIC50:  800nMAssay Description:Inhibition of human HDAC1 after 15 mins by trypsin-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  850nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM119703(US8685992, 27)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC4 (627 to 1085 residues) expressed in baculovirus expression system using AMC-labeled RHKKAc as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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