Compile Data Set for Download or QSAR
maximum 50k data
Found 96 Enz. Inhib. hit(s) with all data for entry = 50012621
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of recombinant human EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate incubate for 15 mins by LANCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of recombinant human YES using biotinyl-beta Abeta-Abeta AYQAEENTYDEYEN as substrate incubate for 30 mins by LANCE assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of ErBB2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human JAK3 using Ulight-CAGAGAIETDKEYYTVKD as substrate incubate for 60 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  29nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant human LCK using Ulight-Poly GAT[EAY(1:1:1)]n as substrate incubate for 10 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  37nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  60nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 5 mins followed by NADPH addition and further incubated for 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  62nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  73nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 4 group A member 3(Homo sapiens)
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  78nMAssay Description:Inhibition of Tec (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  96nMAssay Description:Inhibition of recombinant human FYN using biotinyl-beta Abeta-Abeta AYQAEENTYDEYEN as substrate incubate for 60 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  146nMAssay Description:Inhibition of recombinant human YES using biotinyl-beta Abeta-Abeta AYQAEENTYDEYEN as substrate incubate for 30 mins by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  171nMAssay Description:Inhibition of recombinant human SRC using Ulight-Poly GAT[EAY(1:1:1)]n as substrate incubate for 10 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human LYN using biotinyl-beta Abeta-Abeta AKVEKIGEGTYGVVYK as substrate incubate for 120 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 4 group A member 3(Homo sapiens)
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  211nMAssay Description:Inhibition of Tec (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  259nMAssay Description:Inhibition of recombinant human LYN using biotinyl-beta Abeta-Abeta AKVEKIGEGTYGVVYK as substrate incubate for 120 mins by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  331nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  504nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  637nMAssay Description:Inhibition of recombinant human LCK using Ulight-Poly GAT[EAY(1:1:1)]n as substrate incubate for 10 mins by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  640nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  657nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  810nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558808(CHEMBL4762469)
Affinity DataIC50:  810nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant human SRC using Ulight-Poly GAT[EAY(1:1:1)]n as substrate incubate for 10 mins by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of recombinant human FYN using biotinyl-beta Abeta-Abeta AYQAEENTYDEYEN as substrate incubate for 60 mins by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558802(CHEMBL4756276)
Affinity DataIC50:  1.71E+3nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558809(CHEMBL4798432)
Affinity DataIC50:  1.71E+3nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558800(CHEMBL4752349)
Affinity DataIC50:  1.79E+3nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558801(CHEMBL4798274)
Affinity DataIC50:  2.46E+3nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  3.19E+3nMAssay Description:Inhibition of human liver microsome CYP3A4 using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition and further incubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558798(CHEMBL4791520)
Affinity DataIC50:  3.22E+3nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50:  3.54E+3nMAssay Description:Inhibition of human liver microsome CYP2C9 using tolbutamide as substrate incubated for 5 mins followed by NADPH addition and further incubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  5.55E+3nMAssay Description:Inhibition of recombinant human FMS using Ulight-TK peptide as substrate incubate for 15 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558814(CHEMBL4749370)
Affinity DataIC50:  6.09E+3nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558807(CHEMBL4784737)
Affinity DataIC50:  6.09E+3nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558804(CHEMBL4796406)
Affinity DataIC50:  7.34E+3nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558811(CHEMBL4790832)
Affinity DataIC50:  7.34E+3nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate incubate for 15 mins by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ErBB2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ErBB4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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