Found 18 Enz. Inhib. hit(s) with all data for entry = 50008700 Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Jining Medical University
Curated by ChEMBL
Jining Medical University
Curated by ChEMBL
Affinity DataKi: 6.60nMAssay Description:Displacement of [3H]GR113808 from human 5-HT4R membrane in Tris buffer assessed as inhibitory constant measured after 60 mins by filter binding metho...More data for this Ligand-Target Pair
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
Jining Medical University
Curated by ChEMBL
Jining Medical University
Curated by ChEMBL
Affinity DataKi: 120nMAssay Description:Inhibition of tau aggregation (unknown origin) assessed as inhibitory constantMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
Jining Medical University
Curated by ChEMBL
Jining Medical University
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of tau aggregation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 195nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 232nMAssay Description:Inhibition of human BuChEMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant BACE-1 using 19F peptide as substrate measured after 5 hrs by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibition of BChE (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Jining Medical University
Curated by ChEMBL
Jining Medical University
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant GSK-3beta using 19F peptide as substrate measured after 1.5 hrs by fluorescence methodMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Jining Medical University
Curated by ChEMBL
Jining Medical University
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of BuChE (unknown origin)More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Jining Medical University
Curated by ChEMBL
Jining Medical University
Curated by ChEMBL
Affinity DataIC50: 1.46E+4nMAssay Description:Displacement of [3H]MK-801 from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+6nMAssay Description:Inhibition of BuChE (unknown origin) assessed as decrease in thiocholine accumulation by spectrophotometryMore data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Jining Medical University
Curated by ChEMBL
Jining Medical University
Curated by ChEMBL
Affinity DataEC50: 2.50E+7nMAssay Description:Inhibition of self-induced amyloid beta (1 to 42) (unknown origin) aggregationMore data for this Ligand-Target Pair
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
Jining Medical University
Curated by ChEMBL
Jining Medical University
Curated by ChEMBL
Affinity DataEC50: 130nMAssay Description:Inhibition of tau-tau binding (unknown origin) assessed as increase in dissolved paired helical filamentsMore data for this Ligand-Target Pair
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
Jining Medical University
Curated by ChEMBL
Jining Medical University
Curated by ChEMBL
Affinity DataEC50: 590nMAssay Description:Inhibition of tau aggregation (unknown origin)More data for this Ligand-Target Pair
