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Found 37 Enz. Inhib. hit(s) with all data for entry = 50012914
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561566(CHEMBL4761068)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561570(CHEMBL4746704)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US10323037, Example 110 | US9951077, 110)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561575(CHEMBL4758840)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561574(CHEMBL4752442)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561568(CHEMBL4785747)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561567(CHEMBL4748568)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561571(CHEMBL4784750)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561578(CHEMBL4759591)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561572(CHEMBL4748236)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561576(CHEMBL4756629)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561577(CHEMBL4776688)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561573(CHEMBL4794025)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561569(CHEMBL4764132)
Affinity DataIC50:  46nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561563(CHEMBL4763637)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50175576(CHEMBL3810269)
Affinity DataIC50:  921nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561564(CHEMBL4743952)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561565(CHEMBL4791758)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561562(CHEMBL4751469)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561560(CHEMBL4763135)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561558(CHEMBL4794424)
Affinity DataIC50:  1.68E+3nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561561(CHEMBL4762560)
Affinity DataIC50:  4.66E+3nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US10323037, Example 110 | US9951077, 110)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  9.69E+3nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate preincubated for 10 mins followed by substrate and NADPH addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561559(CHEMBL4750309)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50561557(CHEMBL4745345)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  3.35E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using S-mephenytoin as substrate preincubated for 10 mins followed by substrate and NADPH addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US10323037, Example 110 | US9951077, 110)
Affinity DataIC50:  3.73E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate preincubated for 10 mins followed by substrate and NADPH addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US10323037, Example 110 | US9951077, 110)
Affinity DataIC50:  3.96E+4nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate preincubated for 10 mins followed by substrate and NADPH addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  4.08E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate preincubated for 10 mins followed by substrate and NADPH addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 2C19(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US10323037, Example 110 | US9951077, 110)
Affinity DataIC50:  4.39E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using S-mephenytoin as substrate preincubated for 10 mins followed by substrate and NADPH addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US10323037, Example 110 | US9951077, 110)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate preincubated for 10 mins followed by substrate and NADPH addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human liver microsome CYP2D6 using dextromethorphan as substrate preincubated for 10 mins followed by substrate and NADPH addition and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US10323037, Example 110 | US9951077, 110)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human liver microsome CYP2D6 using dextromethorphan as substrate preincubated for 10 mins followed by substrate and NADPH addition and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate preincubated for 10 mins followed by substrate and NADPH addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed