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Found 9 Enz. Inhib. hit(s) with all data for entry = 50017363
TargetNeutrophil elastase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50601432(CHEMBL5200257)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pnitroanilide as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetNeutrophil elastase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50041292((S)-1-((S)-2-Acetylamino-propionyl)-pyrrolidine-2-...)
Affinity DataKi:  210nMAssay Description:Inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50037115(2-(3-Acetylamino-2-oxo-2H-pyridin-1-yl)-N-(3,3,3-t...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human JAK2 (835 to 1132 residues)More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  300nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  500nMAssay Description:Inhibition of FynT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed