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Found 18 Enz. Inhib. hit(s) with all data for entry = 50015722
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM397428(US9987278, Compound Reference 38)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) incubated for 90 mins in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
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TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM431867(US10550114, Compound 1a)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of 6xHis-tagged full-length wild-type AKT1 (unknown origin) expressed in baculovirus infected Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
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TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM397428(US9987278, Compound Reference 38)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 90 mins in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50: <1.20nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US11136320, Reference Compound | US9266883, 83)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human FGFR4 (447 to 753 residues) incubated for 30 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50233461(CHEMBL4068896)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST-fused human FGFR4 (460 to 802 residues) expressed in baculovirus expression system by enzymatic methodMore data for this Ligand-Target Pair
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TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50514534(CHEMBL4515441)
Affinity DataIC50:  3nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
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TargetCyclin-dependent kinase 13/Cyclin-K(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50:  69nMAssay Description:Inhibition of recombinant CDK13/Cyclin K (unknown origin) expresssed in baculovirus infected insect cells using peptide substrate incubated for 30 mi...More data for this Ligand-Target Pair
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TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM316639(US11111242, Example 130 | US9617258, Example 130)
Affinity DataIC50:  75nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCyclin-dependent kinase 12(Homo sapiens)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50:  158nMAssay Description:Inhibition of recombinant CDK12/Cyclin K (unknown origin) expresssed in baculovirus infected insect cells using peptide substrate incubated for 30 mi...More data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  320nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of His-tagged recombinant human FGFR1 (308 to 731 residues) expressed in baculovirus expression system using Lance ULight poly-GT as subst...More data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of His/TEV-tagged FGFR4 (447 to 753 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using Lance ULight poly-...More data for this Ligand-Target Pair
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LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of recombinant full length human CDK7/C-terminal His-tagged Cyclin H/N-terminal GST-tagged MAT1 expressed in baculovirus in Sf21 insect ce...More data for this Ligand-Target Pair
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