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Found 56 Enz. Inhib. hit(s) with all data for entry = 50016863
TargetHistone deacetylase 6(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of N-terminal GST-tagged HDAC6 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of full-length recombinant human HDAC6 using RHKKAc peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM249366(US9464073, 003 | US9884850, Compound 3)
Affinity DataIC50:  3nMAssay Description:Inhibition of HDAC6 (unknown origin) using acetyl-lysine tripeptide substrate as substrate preincubated for 24 hrs followed by substrate addition by ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139323(US8614223, 101)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of N-terminal GST-tagged HDAC6 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human HDAC6 using RHKKAc peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50597848(CHEMBL5205841)
Affinity DataIC50:  40nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50:  48nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50:  51nMAssay Description:Inhibition of HDAC3 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50:  56nMAssay Description:Inhibition of recombinant human HDAC6 using fluorescent substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50:  58nMAssay Description:Inhibition of HDAC1 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50369345(CHEMBL4165724 | US11207431, Example 1 | US11890356...)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant human HDAC6 using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Affinity DataIC50:  94nMAssay Description:Inhibition of N-terminal GST-tagged HDAC1 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50:  100nMAssay Description:Inhibition of HDAC8 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50597848(CHEMBL5205841)
Affinity DataIC50:  107nMAssay Description:Inhibition of PDE9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Affinity DataIC50:  128nMAssay Description:Inhibition of N-terminal GST-tagged HDAC2 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Affinity DataIC50:  218nMAssay Description:Inhibition of N-terminal GST-tagged HDAC3 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50597848(CHEMBL5205841)
Affinity DataIC50:  593nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  854nMAssay Description:Inhibition of recombinant human HDAC8 using RHKAcKAc peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of HDAC7 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant human HDAC4 using fluorescent substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139323(US8614223, 101)
Affinity DataIC50:  2.12E+3nMAssay Description:Inhibition of N-terminal GST-tagged HDAC1 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139323(US8614223, 101)
Affinity DataIC50:  2.57E+3nMAssay Description:Inhibition of N-terminal GST-tagged HDAC2 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of recombinant human HDAC8 using fluorescent substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of recombinant human HDAC1 using fluorescent substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of recombinant human HDAC10 using fluorescent substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  3.26E+3nMAssay Description:Inhibition of recombinant human HDAC1 using RHKKAc peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  3.46E+3nMAssay Description:Inhibition of full-length recombinant human HDAC9 using Boc-Lys(trifluoroacetyl)-AMC peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50597848(CHEMBL5205841)
Affinity DataIC50:  3.53E+3nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  3.58E+3nMAssay Description:Inhibition of recombinant human HDAC2 using RHKKAc peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  3.72E+3nMAssay Description:Inhibition of full-length recombinant human HDAC8 using RHKAcKAc peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  4.07E+3nMAssay Description:Inhibition of full-length recombinant human HDAC5 using Boc-Lys(trifluoroacetyl)-AMC peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of recombinant human HDAC2 using fluorescent substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  4.55E+3nMAssay Description:Inhibition of full-length recombinant human HDAC7 using Boc-Lys(trifluoroacetyl)-AMC peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50369345(CHEMBL4165724 | US11207431, Example 1 | US11890356...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of recombinant human HDAC7 using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  4.95E+3nMAssay Description:Inhibition of recombinant human HDAC3/NcoR2 using RHKKAc peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of HDAC5 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50369345(CHEMBL4165724 | US11207431, Example 1 | US11890356...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of recombinant human HDAC9 using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  5.23E+3nMAssay Description:Inhibition of full-length recombinant human HDAC1 using RHKKAc peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  5.72E+3nMAssay Description:Inhibition of full-length recombinant human HDAC11 using Boc-Lys(trifluoroacetyl)-AMC peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of HDAC4 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50369345(CHEMBL4165724 | US11207431, Example 1 | US11890356...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of recombinant human HDAC8 using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50369345(CHEMBL4165724 | US11207431, Example 1 | US11890356...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC1 using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50369345(CHEMBL4165724 | US11207431, Example 1 | US11890356...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant human HDAC11 using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50369345(CHEMBL4165724 | US11207431, Example 1 | US11890356...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC3 using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50369345(CHEMBL4165724 | US11207431, Example 1 | US11890356...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC10 using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC9 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50369345(CHEMBL4165724 | US11207431, Example 1 | US11890356...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC2 using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50597848(CHEMBL5205841)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
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