Compile Data Set for Download or QSAR
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Found 20 Enz. Inhib. hit(s) with all data for entry = 50015181
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataKi:  0.830nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataKi:  14.2nMAssay Description:Covalent inhibition of human full length N-terminal GST-fused MPS1 (1 to 857 residues) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM258444(US9512130, 2)
Affinity DataIC50: <1nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM258444(US9512130, 2)
Affinity DataIC50: <1nMAssay Description:Displacement of tracer K9 from NanoLuc-fused MPS1 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM532292(JGS79C | N-(2,6-diethylphenyl)-2-[2-methoxy-4-(4-m...)
Affinity DataIC50: <1nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM532292(JGS79C | N-(2,6-diethylphenyl)-2-[2-methoxy-4-(4-m...)
Affinity DataIC50:  4.70nMAssay Description:Displacement of tracer K9 from NanoLuc-fused MPS1 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583521(CHEMBL5077230)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50446445(CHEMBL2140523)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate measured after 4 hrs in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate measured after 2 hrs in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  22nMAssay Description:Displacement of tracer K9 from NanoLuc-fused MPS1 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate measured after 1 hr in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583521(CHEMBL5077230)
Affinity DataIC50:  33nMAssay Description:Displacement of tracer K9 from NanoLuc-fused MPS1 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate measured immediately in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50446445(CHEMBL2140523)
Affinity DataIC50:  429nMAssay Description:Displacement of tracer K9 from NanoLuc-fused MPS1 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase beta-2(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of human recombinant P70S6Kbeta expressed in Sf9 insect cells using [KKRNRTLTK] as substrate in presence of [33P]-ATP by radiometric hotsp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  2.75E+3nMAssay Description:Inhibition of human recombinant FGFR4 expressed in Sf9 insect cells using poly[Glu:Tyr] 4:1 as substrate in presence of [33P]-ATP by radiometric hots...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human recombinant MAPKAPK2 expressed in Sf9 insect cells using [KKLNRTLSVA] as substrate in presence of [33P]-ATP by radiometric hotspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human recombinant MAPKAPK3 expressed in Sf9 insect cells using [KKLNRTLSVA] as substrate in presence of [33P]-ATP by radiometric hotspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed