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Found 19 Enz. Inhib. hit(s) with all data for entry = 50005616
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038733((3aS,8aR)-1-ethyl-3a-methyl-1,2,3,3a,8,8a-hexahydr...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038740(CHEMBL61274 | Hexyl-carbamic acid 9-methyl-9-aza-t...)
Affinity DataIC50:  72nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038740(CHEMBL61274 | Hexyl-carbamic acid 9-methyl-9-aza-t...)
Affinity DataIC50:  122nMAssay Description:Inhibitory activity against acetylcholinesterase in mice at the dose of 5.0 mg/kg via peroral administrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038732(CHEMBL413549 | Hexyl-carbamic acid 9-ethyl-9-aza-t...)
Affinity DataIC50:  125nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004000((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)
Affinity DataIC50:  128nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038736(CHEMBL64633 | Hexyl-carbamic acid 9-ethyl-1-methyl...)
Affinity DataIC50:  133nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038731(1,2,3,4-Tetrahydro-acridine | CHEMBL292518)
Affinity DataIC50:  136nMAssay Description:Inhibitory activity against acetylcholinesterase in mice at the dose of 6.6 mg/kg via intraperitoneal administrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038734(CHEMBL64529 | Heptyl-carbamic acid 9-methyl-9-aza-...)
Affinity DataIC50:  143nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038740(CHEMBL61274 | Hexyl-carbamic acid 9-methyl-9-aza-t...)
Affinity DataIC50:  148nMAssay Description:Inhibitory activity against acetylcholinesterase in mice at the dose of 1.2 mg/kg via intraperitoneal administrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  148nMAssay Description:Inhibitory activity against acetylcholinesterase in mice at the dose of 4.8 mg/kg via intraperitoneal administrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038733((3aS,8aR)-1-ethyl-3a-methyl-1,2,3,3a,8,8a-hexahydr...)
Affinity DataIC50:  148nMAssay Description:Inhibitory activity against acetylcholinesterase in mice at the dose of 0.8 mg/kg via intraperitoneal administrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038738(CHEMBL292421 | Heptyl-carbamic acid 9-ethyl-9-aza-...)
Affinity DataIC50:  153nMAssay Description:Inhibitory activity against acetylcholinesterase in mice at the dose of 4.4 mg/kg via intraperitoneal administrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038732(CHEMBL413549 | Hexyl-carbamic acid 9-ethyl-9-aza-t...)
Affinity DataIC50:  156nMAssay Description:Inhibitory activity against acetylcholinesterase in mice at the dose of 1.8 mg/kg via intraperitoneal administrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038734(CHEMBL64529 | Heptyl-carbamic acid 9-methyl-9-aza-...)
Affinity DataIC50:  159nMAssay Description:Inhibitory activity against acetylcholinesterase in mice at the dose of 3.6 mg/kg via intraperitoneal administrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038737(CHEMBL302168 | Heptyl-carbamic acid 9-ethyl-1-meth...)
Affinity DataIC50:  159nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038738(CHEMBL292421 | Heptyl-carbamic acid 9-ethyl-9-aza-...)
Affinity DataIC50:  169nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038735(CHEMBL60379 | Methyl-carbamic acid 9-ethyl-9-aza-t...)
Affinity DataIC50:  171nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50038739(Butyl-carbamic acid 9-ethyl-9-aza-tricyclo[6.3.1.0...)
Affinity DataIC50:  206nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed