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Found 94 Enz. Inhib. hit(s) with all data for entry = 50007870
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity was determined for the alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.550nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068839(1-(3-{[5-Carbamoyl-2,6-dimethyl-4-(4-nitro-phenyl)...)
Affinity DataKi:  0.840nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068828(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  1.87nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068831(1-(3-{[5-Acetyl-2,6-dimethyl-4-(4-nitro-phenyl)-1,...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068830(1-(3-{[5-Carbamoyl-2,6-dimethyl-4-(4-nitro-phenyl)...)
Affinity DataKi:  2.19nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068818(1-(3-{[2,6-Dimethyl-5-methylcarbamoyl-4-(4-nitro-p...)
Affinity DataKi:  2.42nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068825(1-(3-{[5-Acetyl-2,6-dimethyl-4-(4-nitro-phenyl)-1,...)
Affinity DataKi:  2.57nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068836(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  2.88nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068819(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  3.58nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068829(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  3.66nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068827(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  3.72nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068818(1-(3-{[2,6-Dimethyl-5-methylcarbamoyl-4-(4-nitro-p...)
Affinity DataKi:  3.94nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068814(1-{3-[(5-Acetyl-4-benzo[1,3]dioxol-5-yl-2,6-dimeth...)
Affinity DataKi:  4.17nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068824(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  4.79nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068833(1-(3-{[5-Ethylcarbamoyl-2,6-dimethyl-4-(4-nitro-ph...)
Affinity DataKi:  4.82nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068821(1-(3-{[5-Carbamoyl-2,6-dimethyl-4-(4-nitro-phenyl)...)
Affinity DataKi:  5.41nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068835(1-(3-{[5-Carbamoyl-2,6-dimethyl-4-(4-nitro-phenyl)...)
Affinity DataKi:  5.98nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068823(1-(3-{[2,6-Dimethyl-5-methylcarbamoyl-4-(4-nitro-p...)
Affinity DataKi:  6.12nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068832(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  6.17nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068815(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068840(1-{3-[(4-Benzo[1,3]dioxol-5-yl-5-carbamoyl-2,6-dim...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068837(1-(3-{[5-Carbamoyl-2,6-dimethyl-4-(4-nitro-phenyl)...)
Affinity DataKi:  9.05nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068817(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  27nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068834(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  59nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068816(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  63nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068835(1-(3-{[5-Carbamoyl-2,6-dimethyl-4-(4-nitro-phenyl)...)
Affinity DataKi:  156nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068832(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  215nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068828(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  330nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068827(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  390nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068818(1-(3-{[2,6-Dimethyl-5-methylcarbamoyl-4-(4-nitro-p...)
Affinity DataKi:  427nMAssay Description:Binding affinity of the compound was determined for recombinant human 5-hydroxytryptamine 1A receptor using [3H]-5-HT as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068822(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  460nMAssay Description:Binding affinity was determined for the alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068818(1-(3-{[2,6-Dimethyl-5-methylcarbamoyl-4-(4-nitro-p...)
Affinity DataKi:  491nMAssay Description:Binding affinity of the compound was determined for recombinant human Histamine H1 receptor using [3H]-pyrilamine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068824(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  520nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068816(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  530nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068835(1-(3-{[5-Carbamoyl-2,6-dimethyl-4-(4-nitro-phenyl)...)
Affinity DataKi:  585nMAssay Description:Binding affinity was determined for the alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068828(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  600nMAssay Description:Binding affinity was determined for the alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068832(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  630nMAssay Description:Binding affinity was determined for the alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068819(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  700nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068814(1-{3-[(5-Acetyl-4-benzo[1,3]dioxol-5-yl-2,6-dimeth...)
Affinity DataKi:  720nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068827(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  740nMAssay Description:Binding affinity was determined for the alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068824(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  750nMAssay Description:Binding affinity was determined for the alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068818(1-(3-{[2,6-Dimethyl-5-methylcarbamoyl-4-(4-nitro-p...)
Affinity DataKi:  760nMAssay Description:Binding affinity of the compound was determined for recombinant human Alpha-2A adrenergic receptor using [3H]-rauwolscine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068836(2,6-Dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataKi:  1.02E+3nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068819(5-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...)
Affinity DataKi:  1.14E+3nMAssay Description:Binding affinity was determined for the alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068825(1-(3-{[5-Acetyl-2,6-dimethyl-4-(4-nitro-phenyl)-1,...)
Affinity DataKi:  1.18E+3nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068831(1-(3-{[5-Acetyl-2,6-dimethyl-4-(4-nitro-phenyl)-1,...)
Affinity DataKi:  1.18E+3nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068818(1-(3-{[2,6-Dimethyl-5-methylcarbamoyl-4-(4-nitro-p...)
Affinity DataKi:  1.28E+3nMAssay Description:Binding affinity of the compound was determined for recombinant human Alpha-2B adrenergic receptor using [3H]-rauwolscine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068821(1-(3-{[5-Carbamoyl-2,6-dimethyl-4-(4-nitro-phenyl)...)
Affinity DataKi:  1.57E+3nMAssay Description:Binding affinity was determined for the alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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