Compile Data Set for Download or QSAR
maximum 50k data
Found 20 Enz. Inhib. hit(s) with all data for entry = 945
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300236(US9593127, Example 10 | tert-butyl 3-[2-(m- tolyl)...)
Affinity DataIC50:  3.65nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300227(US9593127, Example 1 | tert-butyl 3-[2-(3- chlorop...)
Affinity DataIC50:  3.87nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300230(3-[2-(3-chlorophenyl)ethynyl]- N-ethyl-N-isopropyl...)
Affinity DataIC50:  6.99nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300238(US9593127, Example 12 | [3-[2-(m-tolyl)ethynyl]- 3...)
Affinity DataIC50:  10.6nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300234(US9593127, Example 8 | [3-[2-(3-chlorophenyl)ethyn...)
Affinity DataIC50:  12.5nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300240(N,N-diethyl-3-[2-(m- tolyl)ethynyl]-3a,4,5,6a- tet...)
Affinity DataIC50:  14.8nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300235(US9593127, Example 9 | [3-[2-(3-chlorophenyl)ethyn...)
Affinity DataIC50:  15nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300237(US9593127, Example 11 | [3-[2-(m-tolyl)ethynyl]- 3...)
Affinity DataIC50:  17nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300241(N-methoxy-N-methyl-3-[2-(m- tolyl)ethynyl]-3a,4,5,...)
Affinity DataIC50:  22nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300232(US9593127, Example 6 | [3-[2-(3-chlorophenyl)ethyn...)
Affinity DataIC50:  24.8nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300228(US9593127, Example 2 | [3-[2-(3-chlorophenyl)ethyn...)
Affinity DataIC50:  29.6nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300239(US9593127, Example 13 | morpholino-[3-[2-(m- tolyl...)
Affinity DataIC50:  50nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300233(3-[2-(3-chlorophenyl)ethynyl]- N,N-dimethyl-3a,4,5...)
Affinity DataIC50:  59.2nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300229(US9593127, Example 3 | ethyl 3-[2-(3- chlorophenyl...)
Affinity DataIC50:  81.5nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300242(US9593127, Example 16 | ethyl 3-[2-(m-tolyl)ethyny...)
Affinity DataIC50:  152nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300245(N-methoxy-N-methyl-3-[2-(6- methyl-2-pyridyl)ethyn...)
Affinity DataIC50:  239nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300231(US9593127, Example 5 | tert-butyl 3-[2-(6-methyl-2...)
Affinity DataIC50:  708nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300243(US9593127, Example 17 | [3-[2-(6-methyl-2- pyridyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300244(US9593127, Example 18 | [3-[2-(6-methyl-2- pyridyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Recordati Ireland

US Patent
LigandPNGBDBM300246(US9593127, Example 20 | ethyl 3-[2-(6-methyl-2- py...)
Affinity DataIC50: >1.00E+3nMAssay Description:Affinity at transmembrane glutamate metabotropic mGluR5 receptor subtypes was evaluated according to the methods of Anderson (Anderson et al., J Phar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent