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Target
Stimulator of interferon genes protein
Ligand
BDBM576123
Substrate
n/a
Meas. Tech.
3H-cGAMP Filtration Binding Assay
EC50
<1.000±n/a nM
Citation
 Wu, W; Lim, J; Cumming, JN; Trotter, BW; Chang, W Cyclic di-nucleotide compounds as sting agonists US Patent  US11466047 Publication Date 10/11/2022 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM576123
Synonyms:
2-amino-9-[(5S,7R,8R,12aR,14R,15aS)- 14-(4-aminoimidazo[2,1-f][1,2,4]triazin-7- yl)-10-hydroxy-2-sulfanyl-2,10- disulfidooctahydro-12H-5,8- methanofuro[3,2-1][1,3,6,9,11,2,10]penta- oxadiphosphacyclotetradecin-7-yl]-1,9- dihydro-6H-purin-6-one (Diastereomer 1) | US11466047, Example 7 | US11466047, Example 8
Type:
Small organic molecule
Emp. Form.:
C20H24N10O8P2S3
Mol. Mass.:
690.609
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H]2C[C@H]1OP(O)(=S)OC[C@H]1O[C@H](C[C@@H]1OP(S)(=S)OC2)c1cnc2c(N)ncnn12 |r|
Structure:
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