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Target
Protein kinase C beta type Isoform 2
Ligand
BDBM286335
Substrate
n/a
Meas. Tech.
Protein Kinase C beta 2 (PKCpII) Assay
Ki
<10.00±n/a nM
Citation
 Li, H; Nukui, S; Scales, SA; Teng, M; Yin, C Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors US Patent  US11780853 Publication Date 10/10/2023 
Target
Name:
Isoform Beta-II of Protein kinase C beta type (PRKCB2)
Synonyms:
KPCB_HUMAN | PKCB | PRKCB | PRKCB1 | Protein kinase C beta II type | Protein kinase C beta type (PRKCB2)
Type:
Enzyme
Mol. Mass.:
77017.33
Organism:
Homo sapiens (Human)
Description:
P05771-2
Residue:
673
Sequence:
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPEVKS
  
Inhibitor
Name:
BDBM286335
Synonyms:
US11220518, Ex. No. J13 | US11780853, Example J13 | US9518060, Example J13
Type:
Small organic molecule
Emp. Form.:
C24H33F3N8O2
Mol. Mass.:
522.5664
SMILES:
C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(Nc3nccc(n3)C(F)(F)F)n[nH]c2C1(C)C |r|
Structure:
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