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Target
GTPase KRas [G12D]
Ligand
BDBM629505
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.050±n/a nM
Citation
 DAI, C; GUERRERO, JA; GUNEY, T; GUO, H; KATO, D; KIBURU, IN; LAZERWITH, SE; MCKINLEY, JL; MEDLEY, JW; PYUN, H; TIAN, M; TSUI, VH; WATKINS, WJ; ZAJDLIK, AD; ZHANG, JR KRAS G12D MODULATING COMPOUNDS US Patent  US20230339981 Publication Date 10/26/2023 
Target
Name:
GTPase KRas [G12D]
Synonyms:
GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21713.12
Organism:
Homo sapiens (Human)
Description:
P01116[G12D]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM629505
Synonyms:
US20230339981, Example 193
Type:
Small organic molecule
Emp. Form.:
C37H37F3N6O
Mol. Mass.:
638.7245
SMILES:
C[C@H]1Cc2cc(c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5CC[C@H](N5)[C@H]14)c23)-c1cc(N)cc2ccc(F)c(C#C)c12 |r|
Structure:
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