Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group D member 2
Ligand
BDBM643179
Substrate
n/a
Meas. Tech.
FRET Assay for REV-ERB Ligands
IC50
<1000±n/a nM
Citation
 Walker, JK; Burris, TP; Sitaula, S; Chatterjee, A; D''Cunha, NC; Jacobsen, EJ; Blinn, JR REV-ERB AGONISTS US Patent  US20240002380 Publication Date 1/4/2024 
Target
Name:
Nuclear receptor subfamily 1 group D member 2
Synonyms:
EAR-1R | NR1D2 | NR1D2_HUMAN | Orphan nuclear hormone receptor BD73 | Rev-erb-beta | V-erbA-related protein 1-related
Type:
PROTEIN
Mol. Mass.:
64639.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502200
Residue:
579
Sequence:
MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDLANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCNTGGRMHLVCPLSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP
  
Inhibitor
Name:
BDBM643179
Synonyms:
US20240002380, Example 5
Type:
Small organic molecule
Emp. Form.:
C19H14FN3O
Mol. Mass.:
319.3324
SMILES:
Cn1cnc2ccc(Oc3ccccc3-c3cccc(F)c3)nc12
Structure:
Search PDB for entries with ligand similarity: