Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Histamine H1 receptor
Ligand
BDBM50005548
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_1347
Citation
Wong, DT; Threlkeld, PG; Best, KL; Bymaster, FP A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J Pharmacol Exp Ther 222:61-5 (1982) [PubMed] More Info.:
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1_RAT | Hrh1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.35
Organism:
RAT
Description:
HISTAMINE H1 HRH1 RAT::P31390
Residue:
486
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
Inhibitor
Name:
BDBM50005548
Synonyms:
(+)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine | (+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine | (-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine | (Nomifensine) 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine (Nomifensine) | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine(Nomifensine) | 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine | CHEMBL273575 | NOMIFENSINE | NOMIFENSINE2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
Type:
Small organic molecule
Emp. Form.:
C16H18N2
Mol. Mass.:
238.3275
SMILES:
CN1CC(c2ccccc2)c2cccc(N)c2C1
Structure:
