Ki Summary

Reaction Details

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Target

Thromboxane A2 receptor

Ligand

BDBM82228

Substrate

n/a

1500±n/a nM

Comments

PDSP_4879

Citation

Armstrong, RA; Jones, RL; Wilson, NH Ligand binding to thromboxane receptors on human platelets: correlation with biological activity. Br J Pharmacol 79:953-64 (1983) [PubMed] Article

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Target

Name:

Thromboxane A2 receptor

Synonyms:

TA2R_MOUSE | Tbxa2r | Thromboxane A2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

37114.77

Organism:

MOUSE

Description:

Thromboxane A2 TBXA2R MOUSE::P30987

Residue:

341

Sequence:

MWPNGTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAIVASQHAALLDWRATDPSCRLCYFMGVAMVFFGLCPLLLGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSWCFLTLGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFIMQTLLQTPPVMSFSGQLLRATEHQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQAMLSGP

Inhibitor

Name:

BDBM82228

Synonyms:

CAS_74034-56-3 | CTA2

Type:

Small organic molecule

Emp. Form.:

C22H36O3

Mol. Mass.:

348.5194

SMILES:

CCCCC[C@H](O)\C=C\C1C[C@H]2C[C@H](C2)[C@@H]1C\C=C/CCCC(O)=O |r,wU:13.13,15.17,5.5,wD:11.14,THB:16:15:14:12,(-7.11,-1.82,;-5.88,-2.75,;-4.45,-2.15,;-3.22,-3.08,;-1.8,-2.49,;-.58,-3.42,;-.77,-4.96,;.84,-2.83,;2.07,-3.75,;3.49,-3.15,;4.6,-3.53,;5.81,-3.07,;7.11,-3,;5.28,-1.7,;5.81,-.53,;4.01,-2.11,;2.99,-.94,;3.5,.5,;2.49,1.68,;.97,1.39,;-.03,2.55,;-1.54,2.26,;-2.55,3.43,;-4.02,3.17,;-2.04,4.96,)|

Structure: