Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha
Ligand
BDBM50461938
Substrate
n/a
Meas. Tech.
ChEMBL_1772299 (CHEMBL4224411)
IC50
400±n/a nM
Citation
 Brear, P; North, A; Iegre, J; Hadje Georgiou, K; Lubin, A; Carro, L; Green, W; Sore, HF; Hyvönen, M; Spring, DR Novel non-ATP competitive small molecules targeting the CK2 ?/? interface. Bioorg Med Chem 26:3016-3020 (2018) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Inhibitor
Name:
BDBM50461938
Synonyms:
CHEMBL459510 | NSC-7223
Type:
Small organic molecule
Emp. Form.:
C20H13N3O7S
Mol. Mass.:
439.398
SMILES:
Oc1cc(c2cc(ccc2c1\N=N\c1ccc2ccccc2c1O)[N+]([O-])=O)S(O)(=O)=O
Structure:
Search PDB for entries with ligand similarity: