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Target
Neutrophil elastase
Ligand
BDBM50025858
Substrate
n/a
Meas. Tech.
ChEBML_63792
IC50
35800±n/a nM
Citation
 Groutas, WC; Stanga, MA; Brubaker, MJ; Huang, TL; Moi, MK; Carroll, RT Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases. J Med Chem 28:1106-9 (1985) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50025858
Synonyms:
3-Hexadecanoyl-4-hydroxy-6-methyl-pyran-2-one | CHEMBL12738
Type:
Small organic molecule
Emp. Form.:
C22H36O4
Mol. Mass.:
364.5188
SMILES:
CCCCCCCCCCCCCCCC(=O)c1c(O)cc(C)oc1=O
Structure:
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