Reaction Details Report a problem with these data
Target
Similar to alpha-tubulin isoform 1
Ligand
BDBM50059960
Substrate
n/a
Meas. Tech.
ChEMBL_211334 (CHEMBL820777)
IC50
890±n/a nM
Citation
 Chen, K; Kuo, SC; Hsieh, MC; Mauger, A; Lin, CM; Hamel, E; Lee, KH Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization. J Med Chem 40:3049-56 (1997) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Similar to alpha-tubulin isoform 1
Type:
PROTEIN
Mol. Mass.:
10383.05
Organism:
Bos taurus
Description:
ChEMBL_104716
Residue:
99
Sequence:
CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
  
Inhibitor
Name:
BDBM50059960
Synonyms:
2-(3-Chloro-phenyl)-7-methyl-1H-[1,8]naphthyridin-4-one | CHEMBL51139
Type:
Small organic molecule
Emp. Form.:
C15H11ClN2O
Mol. Mass.:
270.714
SMILES:
Cc1ccc2c(O)cc(nc2n1)-c1cccc(Cl)c1
Structure:
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