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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM16415
Substrate
n/a
Meas. Tech.
ChEBML_31634
IC50
2700±n/a nM
Citation
 Sestanj, K; Bellini, F; Fung, S; Abraham, N; Treasurywala, A; Humber, L; Simard-Duquesne, N; Dvornik, D N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor. J Med Chem 27:255-6 (1984) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM16415
Synonyms:
(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetic acid | 2-{2,4-dioxo-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(12),5,7,9(13),10-pentaen-3-yl}acetic acid | Alrestatin | CHEMBL63055 | PiG | Spectrum_001449 | Tocris-0485
Type:
Small organic molecule
Emp. Form.:
C14H9NO4
Mol. Mass.:
255.2256
SMILES:
OC(=O)CN1C(=O)c2cccc3cccc(C1=O)c23
Structure:
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