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Target
Presenilin-1
Ligand
BDBM50485806
Substrate
n/a
Meas. Tech.
ChEMBL_858067 (CHEMBL2166979)
IC50
0.190000±n/a nM
Citation
 Parker, MF; Barten, DM; Bergstrom, CP; Bronson, JJ; Corsa, JA; Dee, MF; Gai, Y; Guss, VL; Higgins, MA; Keavy, DJ; Loo, A; Mate, RA; Marcin, LR; McElhone, KE; Polson, CT; Roberts, SB; Macor, JE 2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as ?-secretase inhibitors. Bioorg Med Chem Lett 22:6828-31 (2012) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50485806
Synonyms:
CHEMBL2164125
Type:
Small organic molecule
Emp. Form.:
C20H25ClN2O4S
Mol. Mass.:
424.941
SMILES:
COc1ccc(CN([C@H](CC(C)C)C(N)=O)S(=O)(=O)c2ccc(Cl)cc2)cc1 |r|
Structure:
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