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Target
Neuropeptide FF receptor 2
Ligand
BDBM50500153
Substrate
n/a
Meas. Tech.
ChEMBL_1543523 (CHEMBL3750524)
Ki
1200±n/a nM
Citation
 Keller, M; Weiss, S; Hutzler, C; Kuhn, KK; Mollereau, C; Dukorn, S; Schindler, L; Bernhardt, G; König, B; Buschauer, A N(?)-Carbamoylation of the Argininamide Moiety: An Avenue to Insurmountable NPY Y1 Receptor Antagonists and a Radiolabeled Selective High-Affinity Molecular Tool ([(3)H]UR-MK299) with Extended Residence Time. J Med Chem 58:8834-49 (2015) [PubMed]  Article 
Target
Name:
Neuropeptide FF receptor 2
Synonyms:
G-protein coupled receptor 74 | G-protein coupled receptor HLWAR77 | GPR74 | NPFF2 | NPFF2_HUMAN | NPFFR2 | NPGPR | Neuropeptide FF receptor 2 | Neuropeptide G-protein coupled receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60293.78
Organism:
Homo sapiens (Human)
Description:
NPFF2 0 HUMAN::Q9Y5X5
Residue:
522
Sequence:
MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
  
Inhibitor
Name:
BDBM50500153
Synonyms:
CHEMBL3746851
Type:
Small organic molecule
Emp. Form.:
C34H38F3N9O6
Mol. Mass.:
725.7174
SMILES:
OC(=O)C(F)(F)F.Cn1cc(CNC(=O)\N=C(\N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 |r|
Structure:
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