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Target
Indoleamine 2,3-dioxygenase 2
Ligand
BDBM50507279
Substrate
n/a
Meas. Tech.
ChEMBL_1829535 (CHEMBL4329409)
IC50
8950±n/a nM
Citation
 Winters, M; DuHadaway, JB; Pham, KN; Lewis-Ballester, A; Badir, S; Wai, J; Sheikh, E; Yeh, SR; Prendergast, GC; Muller, AJ; Malachowski, WP Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase. Eur J Med Chem 162:455-464 (2019) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 2
Synonyms:
I23O2_MOUSE | IDO-2 | Ido2 | Indol1 | Indoleamine 2,3-dioxygenase-like protein 1 | Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Type:
PROTEIN
Mol. Mass.:
45256.34
Organism:
Mus musculus
Description:
ChEMBL_105489
Residue:
405
Sequence:
MEPQSQSMTLEVPLSLGRYHISEEYGFLLPNPLEALPDHYKPWMEIALRLPHLIENRQLRAHVYRMPLLDCRFLKSYREQRLAHMALAAITMGFVWQEGEGQPQKVLPRSLAIPFVEVSRNLGLPPILVHSDLVLTNWTKRNPEGPLEISNLETIISFPGGESLRGFILVTVLVEKAAVPGLKALVQGMEAIRQHSQDTLLEALQQLRLSIQDITRALAQMHDYVDPDIFYSVIRIFLSGWKDNPAMPVGLVYEGVATEPLKYSGGSAAQSSVLHAFDEFLGIEHCKESVGFLHRMRDYMPPSHKAFLEDLHVAPSLRDYILASGPGDCLMAYNQCVEALGELRSYHINVVARYIISAATRARSRGLTNPSPHALEDRGTGGTAMLSFLKSVREKTMEALLCPGA
  
Inhibitor
Name:
BDBM50507279
Synonyms:
CHEMBL4468826
Type:
Small organic molecule
Emp. Form.:
C13H12Cl3NO
Mol. Mass.:
304.599
SMILES:
Cl.NOC(c1ccccc1)c1cccc(Cl)c1Cl
Structure:
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