Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM50514541
Substrate
n/a
Meas. Tech.
ChEMBL_1857507 (CHEMBL4358236)
Ki
9.5±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50514541
Synonyms:
CHEMBL4473045
Type:
Small organic molecule
Emp. Form.:
C27H41N3O
Mol. Mass.:
423.6339
SMILES:
CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1cc(CN2CC[C@@H](O)C2)c2ccccc12 |r,wD:6.9,3.2,22.24,(23.74,-8.52,;22.92,-7.21,;23.66,-5.85,;21.38,-7.25,;20.57,-5.95,;19.03,-5.99,;18.3,-7.34,;19.12,-8.66,;20.65,-8.61,;16.76,-7.4,;16.04,-8.75,;14.5,-8.81,;13.68,-7.5,;14.4,-6.14,;15.95,-6.09,;12.15,-7.56,;11.2,-6.34,;9.75,-6.87,;8.48,-6.01,;7.1,-6.68,;5.74,-5.97,;4.64,-7.04,;5.31,-8.41,;4.59,-9.77,;6.83,-8.2,;9.81,-8.41,;8.71,-9.47,;9.08,-10.97,;10.56,-11.38,;11.66,-10.31,;11.29,-8.84,)|
Structure:
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