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Target
Nociceptin receptor
Ligand
BDBM50514546
Substrate
n/a
Meas. Tech.
ChEMBL_1857507 (CHEMBL4358236)
Ki
23±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50514546
Synonyms:
CHEMBL4521436
Type:
Small organic molecule
Emp. Form.:
C29H46N4O
Mol. Mass.:
466.7017
SMILES:
CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1cc(CNC(=O)CCCCCN)c2ccccc12 |r,wD:6.9,3.2,(30.71,-51.51,;29.9,-50.19,;30.64,-48.83,;28.36,-50.23,;27.55,-48.92,;26,-48.97,;25.27,-50.32,;26.09,-51.64,;27.62,-51.59,;23.73,-50.38,;23,-51.74,;21.47,-51.79,;20.64,-50.48,;21.37,-49.12,;22.92,-49.07,;19.11,-50.54,;18.16,-49.32,;16.71,-49.84,;15.44,-48.99,;14.06,-49.66,;12.78,-48.81,;12.89,-47.27,;11.4,-49.48,;10.13,-48.62,;8.75,-49.3,;7.47,-48.44,;6.09,-49.12,;4.82,-48.26,;16.77,-51.39,;15.66,-52.46,;16.04,-53.95,;17.52,-54.37,;18.62,-53.29,;18.25,-51.82,)|
Structure:
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