Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine kinase 1
Ligand
BDBM50519643
Substrate
n/a
Meas. Tech.
ChEMBL_1877323 (CHEMBL4378717)
Ki
691±n/a nM
Citation
 Zhuang, C; Chen, F Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives. J Med Chem 63:1490-1510 (2020) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine kinase 1
Synonyms:
Receptor (TNFRSF)-interacting serine-threonine kinase 1 (Predicted) | Receptor-interacting serine/threonine kinase 1 | Ripk1 | Synonyms=Ripk1_predicted
Type:
PROTEIN
Mol. Mass.:
74757.59
Organism:
Rattus norvegicus
Description:
ChEMBL_118862
Residue:
658
Sequence:
MQPDMSLDNIKMASDDLLERKDLDSGGFGKVSLCFHRTHGFVILKKVYTGPNRAEYNEALLEEGKMMHRLRHDRVVKLLGIIIEEGNYSLVMEYMEQGNLMHVLKTKESVPLSVKGRIIVEIIEGMHYLHDEGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEEHNKQREASSVTKKNGGTLYYMAPEHLTDINTKPTEKSDVYSFAIVLWAIFANKEPYENVICTEQFLVCINSGNRPNVEDILEFCPREIISLMERCWQTNPEDRPTFFGIEKEFKPFYLSQFEEYVEEDVASLKKEYPSQSPVLKRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLPMGPVEESWFSSSPEYPQEENERSVQAKLQEEASYHAFGIFAEKQTKSQPRLNEAYNREEERKRRVSHDPFAQQRVHENVKSAGAKGLPYPSTTSHGNAAHQLSGPASQIKVPLWNNGVYNHHGFGATGTGVWYGPSVSQSYNAYKTPVPETNLPGSIPTMPYISLAPPDDSIRCTIYNSSRVQIGNYNYMDLGPSSQPPTNTCKVESTSRHQAVFANTTSLTDKHLNPIRENMGKQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRTDLLNQLIQASQS
  
Inhibitor
Name:
BDBM50519643
Synonyms:
CHEMBL4455611
Type:
Small organic molecule
Emp. Form.:
C24H25N5O3
Mol. Mass.:
431.487
SMILES:
COc1ccc2N(C)C(=O)[C@H](CCc2c1)NC(=O)c1nc2CC[C@@H](c3ccccc3)n2n1 |r|
Structure:
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