Reaction Details Report a problem with these data
Target
Deoxyhypusine hydroxylase
Ligand
BDBM47715
Substrate
n/a
Meas. Tech.
ChEMBL_1898739 (CHEMBL4400854)
IC50
5000±n/a nM
Citation
 Jiang, Z; You, Q; Zhang, X Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective. Eur J Med Chem 165:172-197 (2019) [PubMed]  Article 
Target
Name:
Deoxyhypusine hydroxylase
Synonyms:
1.14.99.29 | DOHH | DOHH_HUMAN | Deoxyhypusine dioxygenase | Deoxyhypusine hydroxylase | Deoxyhypusine monooxygenase | HEAT-like repeat-containing protein 1 | HLRC1 | Synonyms=HLRC1 | hDOHH
Type:
PROTEIN
Mol. Mass.:
32886.24
Organism:
Homo sapiens
Description:
ChEMBL_119191
Residue:
302
Sequence:
MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGAPS
  
Inhibitor
Name:
BDBM47715
Synonyms:
DEFEROXAMINE | DEFEROXAMINE MESYLATE | MLS000028713 | N''-(5-azanylpentyl)-N-[5-[[4-[5-[ethanoyl(oxidanyl)amino]pentylamino]-4-oxidanylidene-butanoyl]-oxidanyl-amino]pentyl]-N''-oxidanyl-butanediamide;methanesulfonic acid | N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-1,4-dioxobutyl]-hydroxyamino]pentyl]-N''-(5-aminopentyl)-N''-hydroxybutanediamide;methanesulfonic acid | N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-keto-butanoyl]-hydroxy-amino]pentyl]-N'-(5-aminopentyl)-N'-hydroxy-succinamide;mesylic acid | N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N''-(5-aminopentyl)-N''-hydroxybutanediamide;methanesulfonic acid | SMR000058548 | cid_62881
Type:
Small organic molecule
Emp. Form.:
C25H48N6O8
Mol. Mass.:
560.684
SMILES:
CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
Structure:
Search PDB for entries with ligand similarity: