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Target
Tyrosine-protein kinase Fgr
Ligand
BDBM50354486
Substrate
n/a
Meas. Tech.
ChEMBL_1983549 (CHEMBL4616955)
Ki
3467±n/a nM
Citation
 Hu, H; Bajorath, J Exploring structure-promiscuity relationships using dual-site promiscuity cliffs and corresponding single-site analogs. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Fgr
Synonyms:
FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr
Type:
protein
Mol. Mass.:
59469.88
Organism:
Homo sapiens (Human)
Description:
P09769
Residue:
529
Sequence:
MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
  
Inhibitor
Name:
BDBM50354486
Synonyms:
CHEMBL411043
Type:
Small organic molecule
Emp. Form.:
C20H18ClN5
Mol. Mass.:
363.843
SMILES:
ClC(Cn1ncc2c(NCc3ccccc3)ncnc12)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: