Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein
Ligand
BDBM50547942
Substrate
n/a
Meas. Tech.
ChEMBL_2019401 (CHEMBL4672979)
EC50
1.000000±n/a nM
Citation
 Sabnis, RW Novel Compounds as STING Modulators for Treating Hepatitis B Virus Infections. ACS Med Chem Lett 11:2372-2373 (2020) [PubMed]  Article 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50547942
Synonyms:
CHEMBL4764478
Type:
Small organic molecule
Emp. Form.:
C36H42N10O4
Mol. Mass.:
678.7833
SMILES:
CCn1nc(C)cc1C(=O)\N=c1/n(C)c2ccccc2n1C\C=C\Cn1c2c(cccc2n(C)\c1=N/C(=O)c1cc(C)nn1CC)C(O)CO
Structure:
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