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Target
TGF-beta receptor type-2
Ligand
BDBM50560467
Substrate
n/a
Meas. Tech.
ChEMBL_2072226 (CHEMBL4727760)
IC50
587±n/a nM
Citation
 Engers, DW; Bollinger, SR; Felts, AS; Vadukoot, AK; Williams, CH; Blobaum, AL; Lindsley, CW; Hong, CC; Hopkins, CR Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-2
Synonyms:
TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
64559.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586859
Residue:
567
Sequence:
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
  
Inhibitor
Name:
BDBM50560467
Synonyms:
CHEMBL4788859
Type:
Small organic molecule
Emp. Form.:
C27H24FN5
Mol. Mass.:
437.5114
SMILES:
Cc1cc(-c2cnc3cc(ccn23)-c2ccc(cc2)N2CCNCC2)c2cc(F)ccc2n1
Structure:
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