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Target
Cytochrome P450 2C19
Ligand
BDBM50567966
Substrate
n/a
Meas. Tech.
ChEMBL_2104171 (CHEMBL4812674)
IC50
4000±n/a nM
Citation
Palmer, MJ; Deng, X; Watts, S; Krilov, G; Gerasyuto, A; Kokkonda, S; El Mazouni, F; White, J; White, KL; Striepen, J; Bath, J; Schindler, KA; Yeo, T; Shackleford, DM; Mok, S; Deni, I; Lawong, A; Huang, A; Chen, G; Wang, W; Jayaseelan, J; Katneni, K; Patil, R; Saunders, J; Shahi, SP; Chittimalla, R; Angulo-Barturen, I; Jiménez-Díaz, MB; Wittlin, S; Tumwebaze, PK; Rosenthal, PJ; Cooper, RA; Aguiar, ACC; Guido, RVC; Pereira, DB; Mittal, N; Winzeler, EA; Tomchick, DR; Laleu, B; Burrows, JN; Rathod, PK; Fidock, DA; Charman, SA; Phillips, MA Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. J Med Chem 64:6085-6136 (2021) [PubMed] Article
More Info.:
Target
Name:
Cytochrome P450 2C19
Synonyms:
(R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C
Type:
Enzyme
Mol. Mass.:
55935.47
Organism:
Homo sapiens (Human)
Description:
P33261
Residue:
490
Sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV